LINDERANE Chemical Properties

Melting point:

190～191℃

Boiling point:

434.5±45.0 °C(Predicted)

Density 

1.30±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

Safety Information

Safety Statements 

24/25

HS Code 

29322090

LINDERANE Usage And Synthesis

Description

Linderane is a sesquiterpene that has been found in L. aggregata. It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (K_i = 1.26 μM) in an irreversible and NADPH-dependent manner. Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes. In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.

Uses

Linderane is a sequiterpene lactone extract from Lindera strychnifolia compound used as a cytotoxic agent against hepaic stellate cells.

Definition

ChEBI: Linderane is a member of dioxanes.

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