5-AMINO-3-CHLOROPYRIDAZINE Chemical Properties

Melting point:

153-154 ºC

Boiling point:

368.3±22.0 °C(Predicted)

Density 

1.437

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

4.55±0.10(Predicted)

form 

solid

color 

Light yellow to light brown

Safety Information

HS Code 

2933399990

5-AMINO-3-CHLOROPYRIDAZINE Usage And Synthesis

Uses

6-Chloro-4-pyridazinamine (cas# 29049-45-4) is a compound useful in organic synthesis.

Synthesis

General procedure for the synthesis of 6-chloro-4-amino pyridazine from 3,5-dichloropyridazine: 3,5-dichloropyridazine (1 g, 6.71 mmol, 1.0 eq.), ammonia (8 mL), and dioxane (2 mL) were added to a 25 mL round-bottom flask. The reaction mixture was stirred at 100 °C overnight. Upon completion of the reaction, the resulting solid was collected by filtration. A final 570 mg (62% yield) of 6-chloro-4-aminopyridazine was obtained as a brown solid. The product was analyzed by LC-MS to confirm: (ES, m/z): retention time (RT) = 0.434 min, LCMS purity 53%, m/z = 130 [M + 1].

References

[1] Patent: WO2017/181177, 2017, A1. Location in patent: Paragraph 0941-0944

5-AMINO-3-CHLOROPYRIDAZINE(29049-45-4)Related Product Information

• 5-FLUORO-4-IODO-1H-PYRROLO[2,3-B]PYRIDINE
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• 7-BroMo-2-(Methylthio)pyrrolo[1,2-f][1,2,4]triazine
• 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-1-[(4-methylphenyl)sulfonyl]-
• 7-Bromopyrido[3,2-d]pyrimidin-4(3H)-one
• [1-(trifluoromethyl)cyclopropyl]methanamine hydrochloride
• 5,7-Difluoroindole
• 5,6-dichloro-1H-Indole-3-carboxaldehyde
• 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE
• 6-Nitroindole
• 3-Chloro-6-iodopyridazine
• 1-(Trifluoromethyl)cyclopropanemethanol