ChemicalBook > Product Catalog > API > Digestive system drugs > Gastrointestinal antispasmodic drugs > Drotaverine hydrochloride
Drotaverine hydrochloride
Drotaverine hydrochloride Basic information
- Product Name:
- Drotaverine hydrochloride
- Synonyms:
-
- 1,2,3,4-Tetrahydro-6,7-diethoxy-1-((3,4-diethoxyphenyl) methylene)-isoquinoline hydrochloride
- 1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydro-isoquinolin
- Tetraspasmin-Lef
- (Z)-1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
- DROTAVERINE HYDROCHLORIDE
- DROTAVERINE HCL
- DROTAVERINE HCL ,1-[(3,4-DIETHOXYPHENYL)METHYLENE]-6,7-DIETHOXY 1,2,3,4-TETRAHYDROISOQUINOLINE HCL
- Drotaverinehydrochlorid
- CAS:
- 985-12-6
- MF:
- C24H32ClNO4
- MW:
- 433.97
- EINECS:
- 619-357-4
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Heterocycles
- 985-12-6
- Mol File:
- 985-12-6.mol
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Drotaverine hydrochloride Chemical Properties
- Melting point:
- 208-212°C
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Yellow
- InChI
- InChI=1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13+;
- InChIKey
- JBFLYOLJRKJYNV-UNUAAEKOSA-N
- SMILES
- C1(=C/C2=CC=C(OCC)C(OCC)=C2)/C2=C(C=C(OCC)C(OCC)=C2)CCN/1.[H]Cl
- CAS DataBase Reference
- 985-12-6(CAS DataBase Reference)
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Drotaverine hydrochloride Usage And Synthesis
Chemical Properties
Pale-Yellow Crystalline Solid
Uses
A papaverine analog
Uses
Analogue of Papaverine. Antispasmodic.
Biological Activity
Drotaverine (Drotaverin) is an isoquinoline-based PDE4-selective phosphodiesterase (PDE) inhibitor and an L-type voltage-dependent (voltage-operated) calcium channel (L-VDCC or L-VOCC) blocker th at exhibits in vivo antispasmodic efficacy without anticholinergic effects.', 'It is a benzylisoquinoline derivative. Drotaverine acts as a smooth muscle relaxant.
in vivo
Drotaverine (10-80 mg/kg, i.p., single dose) hydrochloride improves cognitive impairment and shows the ability to regulate levels of neurotransmitters in the brain[3].
| Animal Model: | STZ-induced AD white mice [3] |
| Dosage: | 10, 20, 40, 80 mg/kg; single dose |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Increased physical activity in a dose-dependent manner, with more time spent in the open arms, increased in the number of crossings and time spent in the north quadrant. Increased in brain antioxidant levels (SOD, CAT, GSH), a reduction in nitrite levels, and significant increased in serotonin, dopamine, and norepinephrine levels. |
IC 50
L-type calcium channel; PDE4
Drotaverine hydrochlorideSupplier
Tianjin Zhangxin Pharmaceutical Technology Co., Ltd Gold
- Tel
- 022-28219283 18522293726
- linda_zxyy@163.com
Wuhan Xinru Chemical Co., Ltd. Gold
- Tel
- 15927387915 15337108568
- 2769903731@qq.com
Jiangxi ravel Biotechnology Co.,Ltd Gold
- Tel
- 400-880-2824; 13184580281
- hj@ruiweier.cn
Shanghai Qiao Chemical Science Co., Ltd Gold
- Tel
- 021-58892003
- info@qiaochem.com
HUBEI HICKS BIOCHEMICAL CO.,LTD Gold
- Tel
- 18696113233
- 15927219311@163.com
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