2,4-DICHLORO-6-METHYLQUINAZOLINE Chemical Properties

Boiling point:

292.4±33.0 °C(Predicted)

Density 

1.418±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-0.30±0.30(Predicted)

form 

Solid

Appearance

White to off-white Solid

Safety Information

HS Code 

2933992000

2,4-DICHLORO-6-METHYLQUINAZOLINE Usage And Synthesis

Synthesis

6-Methylquinazoline-2,4(1H,3H)-dione (550 mg, 3.12 mmol) was used as a starting material, which was dissolved in POCl3 (4.0 mL), followed by the addition of N,N'-diethylaniline (0.5 mL). The reaction mixture was heated to 135 °C and the reaction was stirred at this temperature for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into ice water. The precipitated solid was collected by filtration and dried to afford 2,4-dichloro-6-methylquinazoline (590 mg, 89% yield), which could be used in subsequent steps without further purification.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 461 - 467
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 1, p. 119 - 132
[3] Patent: WO2004/87680, 2004, A1. Location in patent: Page 162
[4] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 308 - 312
[5] Patent: WO2008/16666, 2008, A2. Location in patent: Page/Page column 49

2,4-DICHLORO-6-METHYLQUINAZOLINE(39576-82-4)Related Product Information

• CHLOROETHANE
• 4-CHLORO-6-METHYLQUINAZOLINE
• 2,4-DICHLORO-6-(TRIFLUOROMETHYL)-QUINAZOLINE
• 2,4-DICHLORO-6-METHYLQUINAZOLINE