2-AMINO-3-METHOXYPYRAZINE Chemical Properties

Melting point:

84-85℃

Boiling point:

241℃

Density 

1.224

Flash point:

100℃

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

3.49±0.10(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

HazardClass 

IRRITANT

HS Code 

2933998090

2-AMINO-3-METHOXYPYRAZINE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 2-amino-3-methoxypyrazine from 2-amino-3-chloropyrazine is as follows: Pre-step A: Synthesis of 3-methoxy-2-pyrazinamine 3-Chloro-2-pyrazinamine (200 mg, 1.544 mmol) and sodium methanol (250 mg, 4.63 mmol) were dissolved in methanol (3.9 mL) and the mixture was placed in a microwave reactor, heated to 130°C, and reacted for 60 min. Upon completion of the reaction, the crude product was purified by reversed-phase high performance liquid chromatography (RP-HPLC) to afford 3-methoxy-2-pyrazinamine (113 mg, 0.903 mmol, 59% yield). Mass spectrum (electrospray positive ion mode) m/z: 125.8 ([MH]+).

References

[1] Patent: US2013/345120, 2013, A1. Location in patent: Page/Page column
[2] Patent: US8901119, 2014, B2. Location in patent: Page/Page column

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