N-Succinimidyl 11-(maleimido)undecanoate CAS#: 87981-04-2

N-Succinimidyl 11-(maleimido)undecanoate Basic information

Product Name:

N-Succinimidyl 11-(maleimido)undecanoate

Synonyms:

Maleimide-(CH2)10-COONHS
N-SUCCINIMIDYL 11-MALEIMIDOUNDECANOATE
N-(11-MALEIMIDOUNDECANOYLOXY)SUCCINIMIDE
11-Maleimidoundecanoic acid N-succinimidyl ester
N-(11-Maleimidoundecanoyloxy)succinimide, N-Succinimidyl 11-maleimidoundecanoate
11-(MaleiMido)undecanoic acid N-hydroxysucciniMide ester
NHS-(CH2)10-Mal (KMUS)
1H-Pyrrole-2,5-dione, 1-[11-[(2,5-dioxo-1-pyrrolidinyl)oxy]-11-oxoundecyl]-

CAS:

87981-04-2

MF:

C19H26N2O6

MW:

378.42

Mol File:

87981-04-2.mol

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N-Succinimidyl 11-(maleimido)undecanoate Chemical Properties

Melting point:: 90.0 to 94.0 °C
Boiling point:: 520.4±42.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -2.20±0.20(Predicted)
form: powder to crystal
color: White to Almost white

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Safety Information

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10-21
HS Code: 2925.19.9100

MSDS

Language:English Provider:SigmaAldrich

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N-Succinimidyl 11-(maleimido)undecanoate Usage And Synthesis

Uses

Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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