BENZENEMETHANOL, 2-BROMO-6-NITRO- Chemical Properties

Boiling point:

332.6±27.0 °C(Predicted)

Density 

1.767

refractive index 

1.633

storage temp. 

Sealed in dry,Room Temperature

form 

crystalline powder

pka

13.36±0.10(Predicted)

color 

Gold to faint cream

Safety Information

HS Code 

2906290090

BENZENEMETHANOL, 2-BROMO-6-NITRO- Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-bromo-6-nitrobenzyl ester (536 mg, 1.96 mmol) as raw material for 2-bromo-6-nitrobenzyl alcohol: 2-bromo-6-nitrobenzyl ester was dissolved in 10% aqueous acetic acid (20 mL) and 1.5 mL of acetic acid was added. The reaction mixture was heated to reflux overnight. After the reaction was completed, it was cooled to room temperature and the reaction mixture was extracted with ethyl acetate. The organic phases were combined, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 2-bromo-6-nitrobenzenemethanol (389 mg, 86% yield) as a yellow solid.1H NMR (CDCl3, 300 MHz) δ: 4.93 (d, J = 7.43 Hz), 7.354 (t, J = 8.10 Hz), 7.84 (dd, J = 1.23 Hz, 8.17 Hz), 7.89 (dd, J = 1.22 Hz, 8.03 Hz).

References

[1] Patent: WO2005/67933, 2005, A1. Location in patent: Page/Page column 62-63
[2] Patent: US2011/288086, 2011, A1. Location in patent: Page/Page column 29-30
[3] Patent: EP2592083, 2013, A1. Location in patent: Paragraph 0264
[4] Patent: WO2014/125408, 2014, A2. Location in patent: Page/Page column 21
[5] Patent: CN108191871, 2018, A. Location in patent: Paragraph 0245; 0252-0254

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