Basic information Binding Mode Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Inhibitors >  BIBF-1120

BIBF-1120

Basic information Binding Mode Safety Supplier Related

BIBF-1120 Basic information

Product Name:
BIBF-1120
Synonyms:
  • BIBF-1120
  • BIBF-1120(Vargatef)
  • VARGATEF ( BIBF1120 )
  • Vargatef Base or BIBF-1120
  • BIBF1120,BIBF-1120,Vargatef
  • VargatefTM BIBF
  • 928326-83-4 BIBF-1120
  • CS-76
CAS:
928326-83-4
MF:
C31H33N5O4
MW:
539.633
Product Categories:
  • API
Mol File:
928326-83-4.mol
More
Less

BIBF-1120 Usage And Synthesis

Binding Mode

In the co-crystal structure of nintedanib in complex with VEGFR2, the indolinone core binds to the hinge, forming two hydrogen bonds: the NH group of the indolinone with the amide oxygen of Glu917, and the carbonyl oxygen of the indolinone with the amide NH of Cys919. The methyl ester carbonyl oxygen hydrogen bonds with the side chain amine of Lys868. The external solvent exposed N-methyl amine of piperazine potentially engages in ionic interactions with the carboxylic acid reside of Glu850. An X-ray co-crystal structure of RET kinase domain–nintedanib complex has also been determined. It binds to the RET kinase via three crucial hydrogen bond interactions similar to those observed in its complex with VEGFR2.

Description

BIBF 1120 is a triple kinase inhibitor blocking vascular endothelial growth factor receptor, PDGF receptor, and FGF receptor, which has a potential to inhibit tumor growth and pulmonary fibrosis.

Characteristics

Primary targets: PDGFR; VEGFR; FGFR
Class: receptor tyrosine kinase
Treatment: ILD, IPF
Oral bioavailability = 4.7%
Elimination half-life = 10

Definition

ChEBI: Nintedanib is a member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, a vascular endothelial growth factor receptor antagonist, a fibroblast growth factor receptor antagonist and an angiogenesis inhibitor. It is an aromatic ester, a methyl ester, a member of oxindoles, an enamine, an aromatic amine, an aromatic amide and a N-alkylpiperazine. It is a conjugate base of a nintedanib(1+).

brand name

OfevTM

Anticancer Research

BIBF 1120 is a potent inhibitor of VEGFR as well as PDGF and fibroblast growth factor receptor. In a randomized phase II placebo-controlled trial, patients who had just completed chemotherapy for relapsed ovarian cancer, with evidence of response, but at high risk of further early recurrence were treated with BIBF 1120. The study drug was taken continuously (28-day cycles) for 9 cycles (36 weeks) or until disease progression or patient withdrawal. The 36-week PFS 26-week rates were 16.3% and 5.0% in the BIBF 1120 and placebo groups, respectively (HR 0.65; 95% Cl, 0.42 to 1.02; P = .06). Toxicity was also well tolerated.This has prompted a phase III trial (NCTO1O15118) where BIBF 1120 will be combined with carboplatin/paclitaxel as front-line chemotherapy in ovarian cancer.

Side effects

Most of the adverse effects associated with BTBF-1120 were tolerable. They include diarrhea, nausea, vomiting, abdominal pain, and reversible increase in liver enzymes.

Clinical claims and research

BIBF 1120 is a triple tyrosine kinase inhibitor with efficacy on fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), and on platelet-derived growth factor (PDGF).The activation of these pathways has been implicated in the pathogenesis of experimental fibrosis. In a 12-month phase II trial (the TOMORROW trial) patients who received 150 mg of BIBF 1120 twice daily had a trend toward reduction in the decline of FVC.In addition, there was an improved QOL and a reduction in acute exacerbations of IPF. These results led to a phase III trial. This was designed as two identical phase III studies called INPULSIS-1 and INPULSIS-2. The INPULSIS trials tested the effect on IPF disease progression over 52 weeks using 150 mg of twice daily nintedanib (formerly BIBF 1200) versus placebo. The inclusion criteria included patients diagnosed with idiopathic pulmonary fibrosis based on established criteria.In addition, the participants’ HRCT scans and biopsies, if available, were reviewed by a central radiologist or pathologist to confirm the diagnosis. Enrolled subjects had a FVC which was >50% of the predicted value and a DlCO from 30–79% of predicted values. Published data from the two trials indicated that patients who received nintedanib demonstrated a statistically significant reduction in the rate of decline in lung function compared with the placebo group. In the INPULSIS-2 trial, there was a significant reduction in the time to first acute exacerbation of IPF. This was not replicated in the INPULSIS-1 trial data. The most common side effect for the medication was diarrhea. On the basis of this study, nintedanib is pending evaluation for approval for use in the United States.

BIBF-1120Supplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18934348241
Email
sales4.gd@hwrkchemical.com
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Wuhan Sunrise Technology Development Co., Ltd.
Tel
27-027-83314682 13554138826
Email
whsrtech@vip.163.com