TRIPTOQUINONEB
TRIPTOQUINONEB Basic information
- Product Name:
- TRIPTOQUINONEB
- Synonyms:
-
- TRIPTOQUINONEB
- Triptoquine B
- 1,4,7(4bH)-Phenanthrenetrione, 5,6,8,8a,9,10-hexahydro-8-(hydroxymethyl)-4b,8-dimethyl-2-(1-methylethyl)-, (4bS,8S,8aR)-
- CAS:
- 142937-50-6
- MF:
- C20H26O4
- MW:
- 330.42
- Mol File:
- 142937-50-6.mol
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TRIPTOQUINONEB Chemical Properties
- Boiling point:
- 475.4±45.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 14.25±0.10(Predicted)
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TRIPTOQUINONEB Usage And Synthesis
Uses
Triptoquinone B ((+)-Triptoquinone B), a sesquiterpene alkaloid, is an interleukin-1 inhibitor. Triptoquinone B shows potent inhibitory activities against interleukin 1α and β releases for human peripheral mononuclear cells[1][2].
Definition
ChEBI: An abietane diterpenoid with formula C20H26O4, originally isolated from Tripterygium wilfordii.
target
IL Receptor
IC 50
IL-1
References
[1] Takaishi Y, et, al. Triptoquinone A and B novel interleukin-1 inhibitors from Tripterygium wilfordii var Regeli. Tetrahedron Letters. 1992 Nov; 33(47): 7177-7180.
[2] Wang XD, et, al. Terpene alkaloids from Tripterygium wilfordii. J Asian Nat Prod Res. 2005 Oct;7(5):755-9. DOI:10.1080/1028602042000325618
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