Fmoc-N-amido-PEG1-acid Chemical Properties

Boiling point:

589.9±40.0 °C(Predicted)

Density 

1.261±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

4.29±0.10(Predicted)

form 

Solid

color 

White to off-white

Safety Information

HS Code 

2924297099

Fmoc-N-amido-PEG1-acid Usage And Synthesis

Description

Fmoc-N-amido-PEG1-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Fmoc-NH-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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