1-(2-Chloroethyl)pyrrolidine Hydrochloride Chemical Properties

Melting point:

167-170 °C(lit.)

Boiling point:

237°C(lit.)

Density 

0.4[at 20℃]

vapor pressure 

1.64hPa at 25℃

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Water (Slightly)

form 

Crystalline Powder or Crystals

color 

White to off-white

Water Solubility 

Soluble

Sensitive 

Hygroscopic

BRN 

3677061

InChI

InChI=1S/C6H12ClN.ClH/c7-3-6-8-4-1-2-5-8;/h1-6H2;1H

InChIKey

FSNGFFWICFYWQC-UHFFFAOYSA-N

SMILES

N1(CCCl)CCCC1.[H]Cl

LogP

0.736 at 25℃

CAS DataBase Reference

7250-67-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/22

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

UY0703150

HS Code 

29339900

MSDS

• Language:English Provider:2-Pyrrolidinoethyl chloride hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-(2-Chloroethyl)pyrrolidine Hydrochloride Usage And Synthesis

Chemical Properties

white to off-white crystals or crystalline powder

Uses

1-(2-Chloroethyl)pyrrolidine Hydrochloride is a haloalkyl-substituted pyrrolidine used in the preparation of various pharmaceutical compounds, such as the estrogen receptor antagonist Nafoxidine (N212800) and its analogs.

Purification Methods

Purify the hydrochloride by recrystallisation from isopropanol/di-isopropyl ether (charcoal) and recrystallise it twice more. The free base, b 55-56o/11mm, 60-63o/23mm and 90o/56mm, is relatively unstable and should be converted to the hydrochloride immediately, by dissolving in isopropanol and bubbling dry HCl through the solution at 0o, filtering off the hydrochloride and recrystallising it. The picrate has m 107.3-107.8o (from EtOH) [Cason J Org Chem 24 247 1959, Wright et al. J Am Chem Soc 70 3098 1948]. [Beilstein 20 III/IV 66.]

1-(2-Chloroethyl)pyrrolidine Hydrochloride(7250-67-1)Related Product Information

• N-Methylhomopiperazine
• N-(3-Aminopropyl)-imidazole
• PYRROLIDONE HYDROTRIBROMIDE
• 1-(2-CHLOROETHYL)-PYRROLIDINE
• 1-(2-CHLOROETHYL)PYRROLE
• N-(2-CHLOROETHYL)PYRROLIDINE HYDROCHLORIDE, [2-(N-PYRROLIDINO)ETHYL CHLORIDE HYDROCHLORIDE]
• 2-(2-Chloroethyl)-N-methyl-pyrrolidine hydrochloride
• PYRROLIDINOETHYL CHLORIDE HYDROCHLORIDE,1-(2-CHLOROETHYL)PYRROLIDINE HYDROCHLORIDE