2-bromo-6-methylpyridin-4-amine Chemical Properties

Melting point:

179 °C(Solv: benzene (71-43-2))

Boiling point:

312.9±37.0 °C(Predicted)

Density 

1.593±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

powder

pka

5.55±0.50(Predicted)

color 

White

Safety Information

HS Code 

2933399990

2-bromo-6-methylpyridin-4-amine Usage And Synthesis

Application

4-Amino-2-bromo-6-methylpyridine can be used as an intermediate in organic synthesis. For example, the preparation of 2,4-dibromo-6-methylpyridine follows these steps: Bromine (2.57 g, 16.2 mmol) is added to a solution of 4-amino-2-bromo-6-methylpyridine (1.0 g, 5.4 mmol) cooled to -10 °C in 1.0 mL of 40% HBr aqueous solution, followed by the slow dissolution of sodium nitrite (1.86 g, 27.0 mmol) in 3.0 mL of water. The reaction mixture is warmed to room temperature and stirred for 3 hours. Subsequently, a saturated aqueous solution of sodium bicarbonate is added, and the reaction mixture is extracted with EtOAc (2 × 40 mL). The combined organic layers are washed with a saturated aqueous solution of sodium thiosulfate (2 × 40 mL) and water (2 × 40 mL). The organic layers are dried over sodium sulfate, filtered, and concentrated. The crude product was purified using a Redisep 12g silica gel column (0 to 100% EtOAc/hexane) to give 2,4-dibromo-6-methylpyridine as a colorless oil. XH NMR (300 MHz, CDCl3) Δδ 7.49 (d, J = 1.2 Hz, 1H), 7.28 (d, J = 1.2 Hz, 1H), 2.51 (s, 3H).

2-bromo-6-methylpyridin-4-amine(79055-59-7)Related Product Information

• 4-Bromo-2-methylpyridine