3,5-Dichloro-2-nitropyridine Chemical Properties

Boiling point:

295.7±35.0 °C(Predicted)

Density 

1.629

storage temp. 

2-8°C

pka

-5.50±0.10(Predicted)

form 

solid

color 

Colourless to light yellow

Safety Information

HS Code 

2933399990

3,5-Dichloro-2-nitropyridine Usage And Synthesis

Synthesis

a) Synthesis of 3,5-dichloro-2-nitropyridine: 2-Amino-3,5-dichloropyridine (193 mg, 1.00 mmol) was dissolved in concentrated sulfuric acid (5 mL) and potassium persulfate (K2S2O8, 1.3 g, 5.0 mmol) was added batchwise. The reaction mixture was stirred at room temperature overnight and subsequently poured into crushed ice and neutralized with aqueous sodium bicarbonate (NaHCO3). The product was extracted with dichloromethane (CH2Cl2, 3 x 20 mL), and the organic phase was dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the title compound (123 mg, 63.7% yield).1H-NMR (CDCl3, 400 MHz): δ 8.40 (d, 1H, J = 2.1 Hz), 8.05 (d, 1H, J = 2.1 Hz).

References

[1] Patent: WO2006/47504, 2006, A1. Location in patent: Page/Page column 115-116
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 5, p. 1642 - 1648