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TEBIPENEM PIVOXIL

Basic information Safety Supplier Related

TEBIPENEM PIVOXIL Basic information

Product Name:
TEBIPENEM PIVOXIL
Synonyms:
  • (1R,5S,6S)-6-[1(R)-Hydroxyethyl]-1-methyl-2-[1-(2-thiazolin-2-yl)azetidin-3-ylsulfanyl]-1-carba-2-penem-3-carboxylic acid pivaloyloxymethyl ester
  • Tebipenem Pivoxil
  • [(2,2-Dimethylpropanoyl)oxy]methyl (4R,5S,6S)-3-{[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  • (4R,5S,6S)-3-[[1-(4,5-Dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-Methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid (2,2-DiMethyl-1-oxopropoxy)Methyl Ester
  • [4R-[4α,5β,6β(R*)]]-3-[[1-(4,5-Dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-(1-hydroxyethyl)-4-Methyl-7-oxo-1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid (2,2-DiMethyl-1-oxopropoxy)Methyl Ester
  • OrapeneM
  • ME1211
  • TBPM-PI
CAS:
161715-24-8
MF:
C22H31N3O6S2
MW:
497.63
EINECS:
1308068-626-2
Product Categories:
  • Inhibitors
  • API
Mol File:
161715-24-8.mol
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TEBIPENEM PIVOXIL Chemical Properties

Melting point:
140-142℃
Boiling point:
661.9±65.0 °C(Predicted)
Density 
1.50
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
14.36±0.20(Predicted)
form 
Solid
color 
White
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TEBIPENEM PIVOXIL Usage And Synthesis

Chemical Properties

White Solid

Uses

Tebipenem Pivoxil is an oral carbapenem antibiotic. Tebipenem Pivoxil is absorbed and metabolized into Tebipenem, its active metabolite which showed excellent bactericidal activity against β-lactamase-nonproducing, ampicillin-resistant isolates.

Uses

Tebipenem pivoxil(L-084) is a novel oral carbapenem antibiotic with an IC50 of 100 μg/ml for human CYP isoforms. In mouse, rat, dog and monkey, TBPM-PI were absorbed quickly, and the bioavailability was (71.4, 59.1, 34.8 and 44.9%, respectively. There was

Definition

ChEBI: Tebipenem pivoxil is a member of carbapenems and a pivaloyloxymethyl ester.

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