TEBIPENEM PIVOXIL Chemical Properties

Melting point:

140-142℃

Boiling point:

661.9±65.0 °C(Predicted)

Density 

1.50

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

pka

14.36±0.20(Predicted)

form 

Solid

color 

White

TEBIPENEM PIVOXIL Usage And Synthesis

Chemical Properties

White Solid

Uses

Tebipenem Pivoxil is an oral carbapenem antibiotic. Tebipenem Pivoxil is absorbed and metabolized into Tebipenem, its active metabolite which showed excellent bactericidal activity against β-lactamase-nonproducing, ampicillin-resistant isolates.

Uses

Tebipenem pivoxil(L-084) is a novel oral carbapenem antibiotic with an IC50 of 100 μg/ml for human CYP isoforms. In mouse, rat, dog and monkey, TBPM-PI were absorbed quickly, and the bioavailability was (71.4, 59.1, 34.8 and 44.9%, respectively. There was

Definition

ChEBI: Tebipenem pivoxil is a member of carbapenems and a pivaloyloxymethyl ester.

Biological Activity

Tebipenem pivoxil (L-084I; ME1211; SPR994; Tebi-pivoxil; TBM-PI) corresponds to the orally bioavailable pivalyl ester prodrug form of the carbapenem class broad-spectrum β-lactam antibiotic Tebipenem (LJC 11,036; SPR859; TBM). TBM is potent against both gram-positive and gram-negative bacteria, including penicillin-resistant S. pneumoniae (PRSP) and many β-lactamase-producing strains, while being less effective against methicillin-resistant S. aureus (MRSA), S. marcescens, and P. aeruginosa. TBM is 2- to 64-fold more potent than imipenem, cefdinir, and faropenem against clinical isolates from respiratory and urinary-tract infections.

TEBIPENEM PIVOXIL(161715-24-8)Related Product Information

• Imipenem
• Biapenem
• Cefpirome sulfate
• 2,2'-[Dithiobis(3,1-azetidinediyl)]bis[4,5-dihydrothiazole]
• RCIMVZWCHLOZJH-RRCSTGOVSA-N
• Tebipenem
• Tebipenem Pivoxil Impurity 12
• 3-Hydroxy-1-(1,3-thiazolin-2-yl)azetidine
• S-Azetidin-3-yl ethanethioate HCl
• Fenasi
• AT7519
• Saracatinib
• GO 6976
• Ibrutinib
• LY2811376
• Afatinib