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ChemicalBook >  Product Catalog >  Organic Chemistry >  Ethers and derivatives >  2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

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2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone Basic information

Product Name:
2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Synonyms:
  • Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-
  • 2-BROMO-1-(2,2-DIMETHYL-4H-1,3-BENZODIOXIN-6-YL)ETHANONE
  • 2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
  • 6-Bromoacetyl-2,2-dimethyl-4H-benzo[1,3]dioxine
  • 2-Bromo-1-(2,2-dimethyl-4H-1,3-benzadioxin-6-yl) ethanone
  • BNKY020-VT01
  • Albuterol sulfate iMpurit 2
  • Vilanterol Impurity 8Q: What is Vilanterol Impurity 8 Q: What is the CAS Number of Vilanterol Impurity 8
CAS:
102293-80-1
MF:
C12H13BrO3
MW:
285.13
Mol File:
102293-80-1.mol
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2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone Chemical Properties

Boiling point:
390.4±42.0 °C(Predicted)
Density 
1.415±0.06 g/cm3(Predicted)
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Safety Information

HS Code 
2932990090
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2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone Usage And Synthesis

Synthesis

At about -78° C., sodium bis(trimethylsilyl)amide in tetrahydrofuran (1.0M) (2.9 mL) was added to a solution of 1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone (500 mg; 2.43 mmol; 1.00 equiv) in tetrahydrofuran (20 mL). The solution was stirred at about -78° C. for about 1 hour, and chlorotrimethylsilane (290 mg, 2.64 mmol, 1.09 equiv, 99%) was added. The solution was stirred at about -78° C. for about 30 min, and then bromine (390 mg; 2.41 mmol; 0.99 equiv) was added. The solution was stirred at about -78° C. for about 1 hour, and then an aqueous solution of 5% sodium sulfite and 5% sodium bicarbonate (50 mL) was added. Following standard extractive workup with ethyl acetate, the crude residue was then purified by silica gel column chromotagraphy with ethyl acetate/petroleum ether (1/12) to give the title product as a pale yellow oil 2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone (400 mg; 57% yield).

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