2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone Chemical Properties

Boiling point:

390.4±42.0 °C(Predicted)

Density 

1.415±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

Appearance

White to off-white Solid

InChI

InChI=1S/C12H13BrO3/c1-12(2)15-7-9-5-8(10(14)6-13)3-4-11(9)16-12/h3-5H,6-7H2,1-2H3

InChIKey

SJYXUPGLQCUYJS-UHFFFAOYSA-N

SMILES

C(=O)(C1=CC=C2OC(C)(C)OCC2=C1)CBr

Safety Information

HS Code 

2932990090

2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone Usage And Synthesis

Synthesis

At about -78° C., sodium bis(trimethylsilyl)amide in tetrahydrofuran (1.0M) (2.9 mL) was added to a solution of 1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone (500 mg; 2.43 mmol; 1.00 equiv) in tetrahydrofuran (20 mL). The solution was stirred at about -78° C. for about 1 hour, and chlorotrimethylsilane (290 mg, 2.64 mmol, 1.09 equiv, 99%) was added. The solution was stirred at about -78° C. for about 30 min, and then bromine (390 mg; 2.41 mmol; 0.99 equiv) was added. The solution was stirred at about -78° C. for about 1 hour, and then an aqueous solution of 5% sodium sulfite and 5% sodium bicarbonate (50 mL) was added. Following standard extractive workup with ethyl acetate, the crude residue was then purified by silica gel column chromotagraphy with ethyl acetate/petroleum ether (1/12) to give the title product as a pale yellow oil 2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone (400 mg; 57% yield).

2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone(102293-80-1)Related Product Information

• 2-BROMO-1-[4-HYDROXY-3-(HYDROXYMETHYL)PHENYL]ETHAN-1-ONE
• Ethanol, 2-[(2,6-dichlorophenyl)Methoxy]-
• Benzene, 2-[[2-[(6-broMohexyl)oxy]ethoxy]Methyl]-1,3-dichloro
• 21ξ-morpholino-23,24-dinor-chola-4,20-dien-3-one
• Androstenone hydrazone
• 17-Iodoandrosta-5,16-dien-3beta-ol
• BISNORCHOLENALDEHYDE
• tert-Butyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)carbamate
• CarbaMic acid, [(2R)-2-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester
• 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-
• N-(1-Cyclohexen-1-yl)morpholine
• Abiraterone