Aristolactam BIII
Aristolactam BIII Basic information
- Product Name:
- Aristolactam BIII
- Synonyms:
-
- Aristolactam BIII
- Dibenz[cd,f]indol-4(5H)-one,1,2,9-trimethoxy-
- 1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one
- 1,2,9-Trimethoxydibenz[cd,f]indol-4(5H)-one
- CAS:
- 53948-10-0
- MF:
- C18H15NO4
- MW:
- 309.32
- Mol File:
- 53948-10-0.mol
Aristolactam BIII Chemical Properties
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- powder
- color
- Yellow
Aristolactam BIII Usage And Synthesis
Description
Aristolactam BIII has moderate antitumor activity in selected cell lines. Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, HT-29 and A549 cell lines in vitro.
Uses
Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1].
target
PAFR
References
[1] Miri Choi, et al. Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine. 2021 Nov:92:153695. DOI:10.1016/j.phymed.2021.153695
Aristolactam BIIISupplier
- Tel
- +86-21-20908456
- sales@BioChemBest.com
- Tel
- 0871-65217109 13211707573;
- y.liu@mail.biobiopha.com
- Tel
- 18607101326 15172504745
- aileen@chemfaces.com
- Tel
- 888-539-0666
- info@emmx.com
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com