Brevilin A Chemical Properties

Boiling point:

494.0±45.0 °C(Predicted)

Density 

1.17±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO:100.0(Max Conc. mg/mL);288.67(Max Conc. mM)

form 

A solid

Brevilin A Usage And Synthesis

Uses

Brevilin A can be used using a selective extraction method to obtain natural substances, and can also be applied to prepare derivatives to use for anti-cancer activity.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Enzyme inhibitor

This naturally occurring sesquiterpenoid (FW = 346.40 g/mol; CAS 16503- 32-5) from the volatile oils of the plant Centipeda minima inhibits (IC50 = 10 μg/mL) STAT3 phosphorylation in the Jak/STAT signal transduction pathway of A549R cells. Brevilin A showed high specificity on Janus Kinase activity and following STAT3 signaling without directly affecting some other signals, including p65, AKT and GSK-3β phosphorylation, as well as Src kinase activity. Brevilin A is also an antibiotic with activity against Giardia (IC50 = 16 μM) and Entamoeba histolitica (IC50 = 4–9 μM).

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