CP466722 Chemical Properties

Boiling point:

642.3±65.0 °C(Predicted)

Density 

1.48

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

DMSO: soluble0.5mg/mL, clear (warmed)

pka

0.00±0.19(Predicted)

form 

powder

color 

white to beige

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

CP466722 Usage And Synthesis

Description

CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM. It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC₅₀s = 16.92 and 12.78 μM, respectively).

Uses

CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase

Definition

ChEBI: 2-(6,7-dimethoxy-4-quinazolinyl)-5-(2-pyridinyl)-1,2,4-triazol-3-amine is a member of quinazolines.

target

ATM

References

[1]. guo, k., et al., development of a cell-based, high-throughput screening assay for atm kinase inhibitors. j biomol screen, 2014. 19(4): p. 538-46.
[2]. nadkarni, a., et al., atm inhibitor ku-55933 increases the tmz responsiveness of only inherently tmz sensitive gbm cells. j neurooncol, 2012. 110(3): p. 349-57.
[3]. rainey, m.d., et al., transient inhibition of atm kinase is sufficient to enhance cellular sensitivity to ionizing radiation. cancer res, 2008. 68(18): p. 7466-74.

CP466722(1080622-86-1)Related Product Information

• Y27632 (hydrochloride)
• Gefitinib
• ABT 737
• Sunitinib Malate
• Docetaxel
• Olaparib