1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid Chemical Properties

Melting point:

195-196℃ (acetone ligroine )

Boiling point:

456.6±38.0 °C(Predicted)

Density 

1.422±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder

pka

4.05±0.20(Predicted)

color 

White to off-white

Safety Information

HS Code 

2934999090

1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid Usage And Synthesis

Synthesis

3,3-Dimethyl- 2, 4-dioxa-9-thiaspiro[5.5]undecane-1,5-dione-9, 9-dioxide 1 (20.0 g, 76.3 mmol) and then 6 N hydrochloric acid (60 mL) and Antifoam 204 (200 mg, 1 wt % relative to 1) were charged to a 250-mL, three-neck round-bottom flask, equipped with a mechanical stirrer and a thermocouple. The reaction was then heated to reflux, and the distillate was collected until the internal temperature reached 100 eC; after that, the reaction was allowed to reflux for an additional 8 hours or until LC/MS showed a complete conversion of 1 to 2. The reaction was then cooled to room temperature and held for ~12 h when the product crystallized from the solution. The slurry was cooled to 0 °C for 1 h and then filtered. The cake was dried in a vacuum oven at 60 eC, with nitrogen bleed, overnight to give the product as a white, crystalline solid 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid (8.84 g, 49.6 mmol, 65% yield.

1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid(64096-87-3)Related Product Information

• 2-HYDROXYTETRAHYDROPYRAN
• Tetrahydro-4H-pyran-4-one
• Ethyl tetrahydro-2H-pyran-3-carboxylate
• delta-Valerolactone
• METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE
• ethyl tetrahydro-2H-pyran-2-carboxylate
• METHYL TETRAHYDROPYRAN-3-CARBOXYLATE
• Thian-4-one S-oxide
• Tetrahydrothiopyran-4-one oxiMe
• 2H-Thiopyran-4-carboxaldehyde, tetrahydro-, 1,1-dioxide
• 2H-Thiopyran-3-carboxylicacid,tetrahydro-(9CI)
• tetrahydro-2H-thiopyran-3-carboxylic acid 1,1-dioxide(SALTDATA: FREE)
• tetrahydro-2H-thiopyran-4-carbonitrile 1,1-dioxide(SALTDATA: FREE)
• tetrahydrothiopyran-3-carboxaldehyde
• Fluvastatin lactone-mixture of four isomers
• TETRAHYDRO-2H-PYRAN-3-CARBOXYLIC ACID
• TETRAHYDROTHIOPYRAN-4-OL 97
• Hexahydro-3H-pyrrolo[1,2-c]imidazole-1,3-dione