5-chloro-3-hydroxyisothiazole Chemical Properties

Melting point:

96-97 °C(Solv: water (7732-18-5))

Density 

1.62±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

7.20±0.40(Predicted)

Safety Information

HS Code 

2934100090

5-chloro-3-hydroxyisothiazole Usage And Synthesis

Synthesis

5-chloro-3-hydroxyisothiazole can be synthesized from 3,3'-disulfanediyldipropionic acid and Thionyl chloride in three steps. In particular, in the last step, 5-chloro isothiazolone derivatives (5-chloro-3-hydroxyisothiazole) were the predominant products when the ratio of sulfuryl chloride/amide was 3:1 while with the relevant ratio of 1:1, the 5-unsubstituted analogs were the predominant products[1].

References

[1] Khalaj A, et al. Synthesis and antibacterial activity of 2-(4-substituted phenyl)-3(2H)-isothiazolones. European Journal of Medicinal Chemistry, 2004; 39: 285–290.