4,6-dichloronicotinaldehyde Chemical Properties

Boiling point:

268.2±35.0 °C(Predicted)

Density 

1.488±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

-1.17±0.10(Predicted)

Appearance

White to light green Solid

InChI

InChI=1S/C6H3Cl2NO/c7-5-1-6(8)9-2-4(5)3-10/h1-3H

InChIKey

AKYJFAHYRMPRDS-UHFFFAOYSA-N

SMILES

C1=NC(Cl)=CC(Cl)=C1C=O

Safety Information

HazardClass 

IRRITANT

HS Code 

2933399990

4,6-dichloronicotinaldehyde Usage And Synthesis

Synthesis

Part II- Synthesis of 4,6-dichloropyridine-3-carbaldehyde: (4,6-dichloropyridin-3-yl)methanol (4.9 g, 28 mmol) was dissolved in trichloromethane (100 mL). Subsequently, manganese dioxide (24 g, 280 mmol) was added and the reaction mixture was stirred at 75 °C for 12 hours. Upon completion of the reaction, the mixture was cooled to room temperature, filtered through a pad of diatomaceous earth and the filtrate was concentrated under reduced pressure to give 4,6-dichloropyridine-3-carbaldehyde. The mass of the product was 2.9 g in 90% yield. Liquid chromatography-mass spectrometry (electrospray ionization) analysis: calculated value C6H3Cl2NO = 175; measured value [M + H]+ signal is weak.

References

[1] Patent: WO2013/169704, 2013, A2. Location in patent: Paragraph 0231
[2] Patent: CN106810558, 2017, A. Location in patent: Paragraph 0158; 0162; 0163
[3] Patent: CN106810559, 2017, A. Location in patent: Paragraph 0162; 0167; 0170; 0171
[4] Patent: WO2016/128529, 2016, A1. Location in patent: Paragraph 01364; 01367; 01368
[5] Patent: WO2018/15410, 2018, A1. Location in patent: Paragraph 0284; 0288-0290

4,6-dichloronicotinaldehyde(1060811-62-2)Related Product Information

• 4-Amino-3,5-dichloropyridine