JNJ-10397049
JNJ-10397049 Basic information
- Product Name:
- JNJ-10397049
- Synonyms:
-
- JNJ-10397049
- N-(2,4-DIBROMOPHENYL)-N'-[(4S,5S)-2,2-DIMETHYL-4-PHENYL-1,3-DIOXAN-5-YL]-UREA
- 3-(2,4-DIBROMOPHENYL)-1-[(4S,5S)-2,2-DIMETHYL-4-PHENYL-1,3-DIOXAN-5-YL]UREA
- JNJ-10397049, CID 9869934
- 1-(2,4-dibromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea
- JNJ 10397049; JNJ10397049
- Urea, N-(2,4-dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-
- 1-(2,4-dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-6-yl)urea
- CAS:
- 708275-58-5
- MF:
- C19H20Br2N2O3
- MW:
- 484.18
- Product Categories:
-
- api
- Mol File:
- 708275-58-5.mol
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JNJ-10397049 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble to 100 mM in DMSO and to 100 mM in ethanol
- form
- Powder
- color
- White to off-white
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JNJ-10397049 Usage And Synthesis
Uses
JNJ 10397049 is a selective OX2 receptor antagonist that exhibited sleep promoting effects in rats.
in vivo
JNJ-10397049 (10-30 mg/kg) decreases the latency for persistent sleep and increased nonrapid eye movement and rapid eye movement sleep time[2].
JNJ-10397049 blocks ethanol self-administration, place preference and reinstatement[3].
| Animal Model: | Male Sprague-Dawley rats[2]. |
| Dosage: | 10 mg/kg. |
| Administration: | Subcutaneous administration. |
| Result: | Induced a significant reduction in NREM sleep latency and an increase in NREM sleep duration during the first 2 h after administration relative to vehicle treatment. |
IC 50
OX2 Receptor
storage
Store at +4°C
JNJ-10397049Supplier
J & K SCIENTIFIC LTD.
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- 18210857532; 18210857532
- jkinfo@jkchemical.com
China DongFan Chemical Co.,LTD
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- 86-0571-85151182
AdooQ BioScience, LLC
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- +1 (866) 930-6790
- info@adooq.com
Beyond Pharmaceutical Co., Ltd
- Tel
- 0571-81953185 +86-15381198709
- jasonyao@bydpharma.com
Jinan Yaoyan Pharmaceutical Co., Ltd.
- Tel
- jnyaoyan@163.com