3-Bromo-4-fluoronitrobenzene Chemical Properties

Melting point:

55°C

Boiling point:

250.6±20.0 °C(Predicted)

Density 

1.808±0.06 g/cm3(Predicted)

Flash point:

105°

storage temp. 

Sealed in dry,Room Temperature

form 

Solid

color 

White or Colorless to Light yellow to Light orange

Water Solubility 

Slightly soluble in water.

CAS DataBase Reference

701-45-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

HazardClass 

IRRITANT

HS Code 

29049090

3-Bromo-4-fluoronitrobenzene Usage And Synthesis

Chemical Properties

Light yellow solid

Uses

Reatant in the synthesis of N-fused tricyclic indoles, dimethyamine, benzofuran.

Synthesis Reference(s)

The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o

Synthesis

Example 4: 3.0 g (0.054 mol) of iron powder was added to 250 g (1.77 mol) of 4-fluoronitrobenzene and the mixture was heated to 140 °C. Over a period of 9 hours, 450 g (2.81 mol) of bromine was slowly added dropwise and supplemented with 15 g (0.27 mol) of iron powder in batches. After the dropwise addition was completed, stirring of the reaction mixture was continued for 6 hours. After completion of the reaction, the mixture was filtered and the filtrate was dissolved in 530 g of hot hexane. After cooling the solution, 220 g of 3-bromo-4-fluoronitrobenzene crystals precipitated in a yield of 55.8% of the theoretical value, with the product having a melting point of 55.5°C-56.5°C and a purity of 99.0%.

References

[1] Patent: US4446075, 1984, A

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