Ethyl malonyl chloride Chemical Properties

Boiling point:

79-80 °C25 mm Hg(lit.)

Density 

1.196 g/mL at 20 °C

refractive index 

n20/D 1.429(lit.)

Flash point:

154 °F

storage temp. 

2-8°C

solubility 

Chloroform (Soluble), DMSO (Sparingly), Ethyl Acetate (Slightly)

pka

9.35±0.46(Predicted)

form 

Liquid

Specific Gravity

1.176

color 

Clear yellow to brown

Water Solubility 

REACTS

Sensitive 

Moisture Sensitive

BRN 

636215

Stability:

Hygroscopic, Moisture Sensitive

CAS DataBase Reference

36239-09-5(CAS DataBase Reference)

NIST Chemistry Reference

Ethyl malonyl chloride(36239-09-5)

Safety Information

Hazard Codes 

C

Risk Statements 

14-34

Safety Statements 

7-26-36/37/39-45-36/39

RIDADR 

UN 3265 8/PG 3

WGK Germany 

3

F 

10-21

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

II

HS Code 

29171900

MSDS

• Language:English Provider:Ethyl (chloroformyl)acetate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Ethyl malonyl chloride Usage And Synthesis

Chemical Properties

clear yellow to brown liquid

Uses

Employed in the synthesis of 3-pyrrolin-2-ones via amidation with propargylamines and subsequent base catalyzed 5-exo-dig cyclization.1

Uses

Ethyl malonyl chloride is used in the syntheses of methanofullerodendimers and 3-pyrrolin-2-ones. It plays a vital role in the preparation of 3,5-disubstituted 1,2,4-oxadiazole derivatives, which are potential peptidomimetic building blocks. It is a versatile acylating agent for propargyl alcohols, hydrazines and amines.

General Description

Ethyl malonyl chloride is a versatile acylating agent for propargyl alcohols, hydrazines and amines.

Ethyl malonyl chloride(36239-09-5)Related Product Information

• Ethanol
• Ethyl bromoacetate
• Ethylbenzene
• Ethylparaben
• CHLOROETHANE
• Cellulose acetate
• Ethyl phenylacetate
• Butyl acetate
• Isopropyl acetate
• Ethyl cellulose
• Ammonium acetate
• Epichlorohydrin
• Ethyl acetate
• Magnesium acetate
• Ethyl propionylacetate
• Sodium acetate
• Ethyl acrylate
• Vinyl acetate