Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride Chemical Properties

Melting point:

200 °C

storage temp. 

Inert atmosphere,Room Temperature

Appearance

White to off-white Solid

Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride Usage And Synthesis

Synthesis

Step 1. Preparation of (1R,3S,5S)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride: tert-butyl (1R,3S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate (300 mg, 1.32 mmol) was dissolved in a solution of 1,4-dioxane (4.0 mL) in 4 M HCl and the reaction was stirred at room temperature for 15 hours. After completion of the reaction, the mixture was concentrated under reduced pressure to give the target product (168 mg, quantitative yield) as a white solid, which could be used in subsequent steps without further purification.LC-MS analysis: calculated value 127.1 [M + H]+, measured value 127.90 [M + H]+.

References

[1] Patent: US2012/53180, 2012, A1. Location in patent: Page/Page column 35
[2] Patent: WO2013/61305, 2013, A1. Location in patent: Page/Page column 44

Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride(17366-48-2)Related Product Information

• rac trans-Lafutidine
• exo-9-Azabicyclo[3.3.1]nonan-3-ol hydrochloride
• exo-8-Oxabicyclo[3.2.1]octan-3-ol
• methyl exo-9-azabicyclo[3.3.1]nonane-3-carboxylate hydrochloride
• exo-8-Azabicyclo[3.2.1]octane-3-Methanol hydrochloride
• exo-8-Azabicyclo[3.2.1]octan-2-carboxylic acid
• Methyl exo-8-azabicyclo[3.2.1]octan-2-carboxylate
• exo-8-Azabicyclo[3.2.1]octane-3-carbonitrile
• exo-8-Azabicyclo[3.2.1]octan-2-ol
• exo-8-Azabicyclo[3.2.1]octane-3-carbonitrile hydrochloride
• (1α,5α)-8-Azabicyclo[3.2.1]octane-3α-ol
• exo-8-Azabicyclo[3.2.1]octane-3-carboxylic acid hydrochloride