1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid Chemical Properties

Melting point:

>147°C (dec.)

Boiling point:

836.7±75.0 °C(Predicted)

Density 

1.77±0.1 g/cm3(Predicted)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

Methanol (Slightly, Heated)

form 

Solid

pka

2.66±0.70(Predicted)

color 

Off-White to Pale Yellow

Stability:

Hygroscopic

1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid Usage And Synthesis

Description

Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib . Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC₅₀s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). Celecoxib carboxylic acid acyl-β-D-glucuronide is a minor metabolite, accounting for 2% of the administered dose in human urine and rat bile.

Uses

Celecoxib Carboxylic Acid Acyl-β-D-glucuronide is a glucuronide metabolite of Celecoxib (C251000), a Cox-2 inhibitor.

References

[1] S K PAULSON. Metabolism and excretion of [(14)C]celecoxib in healthy male volunteers.[J]. Drug Metabolism and Disposition, 2000, 28 3: 308-314.
[2] YONG MA  Ming H  Song Gao. Quantitation of celecoxib and four of its metabolites in rat blood by UPLC-MS/MS clarifies their blood distribution patterns and provides more accurate pharmacokinetics profiles[J]. Journal of Chromatography B, 2015, 1001: Pages 202-211. DOI: 10.1016/j.jchromb.2015.07.026
[3] Y. AMY SIU . Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants[J]. Drug Metabolism and Pharmacokinetics, 2018, 33 5: Pages 219-227. DOI: 10.1016/j.dmpk.2018.06.001

1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid(264236-79-5)Related Product Information

• Celecoxib Impurity 24
• HYDROXYMETHYL CELECOXIB
• Celecoxib Trifluro Impurity
• Celecoxib 2-Methyl Analog
• Celecoxib
• N-De(4-sulfonaMidophenyl)-N'-(4-sulfonaMidophenyl) Celecoxib
• CELECOXIB CARBOXYLIC ACID
• Celecoxib Impurity
• N-(P-SULFAMOYLPHENETHYL)ACETAMIDE
• 4-[1-[4-(AMINOSULFONYL)PHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-5-YL]BENZOIC ACID
• 1-HEXADECANOYL-2-(P-NITROPHENOXYSUCCINOYL)-SN-GLYCERYL-3-PHOSPHORYLCHOLINE
• 4-[5-hydroxy-3-(4-methylphenyl)-5-(trifluoromethyl)-4H-pyrazol-1-yl]benzenesulfonamide
• 5-(TRIFLUOROMETHYL)-3-P-TOLYL-1H-PYRAZOLE
• 4-[[3-(4-Methylphenyl)-3-oxo-1-(trifluoroMethyl)propylidene]aMino]benzenesulfonaMide
• Celecoxib iMpurity-G
• 4-Hydrazinobenzene-1-sulfonamide hydrochloride
• 4-DesMethyl-3-Methyl Celecoxib
• Celecoxib Impurity