Fatostatin A
Fatostatin A Basic information
- Product Name:
- Fatostatin A
- Synonyms:
-
- 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole
- 125B11
- Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-
- 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole
- mice,125B11,prostate,cancer,Fatty Acid Synthase (FASN),gene,human,insulin-induced,Fatostatin,ob/ob,inhibit,expression,Golgi,Inhibitor,adipogenesis,SREBP-mediated
- Fatostatin, 10 mM in DMSO
- CAS:
- 125256-00-0
- MF:
- C18H18N2S
- MW:
- 294.41
- Mol File:
- 125256-00-0.mol
Fatostatin A Chemical Properties
- Boiling point:
- 474.3±55.0 °C(Predicted)
- Density
- 1.125±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- pka
- 3.46±0.10(Predicted)
- form
- solid
- color
- Yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Fatostatin A Usage And Synthesis
Description
Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice.1?Inhibits high glucose-induced TGF-β in mesangial cells.2?Cell permeable.
Uses
Fatostatin A is Cell permeable inhibitor of SREBP activation.
Definition
ChEBI: 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)thiazole is a member of thiazoles.
in vivo
Fatostatin (125B11) (30 mg/kg; 150 μL; i.p. injection; daily for 28 days) reduces adiposity, ameliorated fatty liver by reducing triglyceride (TG) storage, and lowered hyperglycemia in ob/ob mice[2].
| Animal Model: | Four-to-five-week-old homozygous male obese (ob/ob) mice (C57BL/6J)[2] |
| Dosage: | 30 mg/kg; 150 μL |
| Administration: | i.p. injection; daily for 28 days |
| Result: | Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake. |
References
[1] SHINJI KAMISUKI. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.[J]. Chemistry & biology, 2009: 882-892. DOI:10.1016/j.chembiol.2009.07.007
[2] LALITA UTTARWAR. SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells.[J]. American Journal of Physiology-renal Physiology, 2012, 302 3: F329-41. DOI:10.1152/ajprenal.00136.2011
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