SQ 109
SQ 109 Basic information
- Product Name:
- SQ 109
- Synonyms:
-
- SQ 109
- NSC 722041
- N-[(2E)-3,7-Dimethyl-2,6-octadienyl]-N'-tricyclo[3.3.1.1(3,7)]dec-2-yl-1,2-ethanediamine
- Cenobamate
- N'-(2-adamantyl)-N-[(2E)-3,7-dimethylocta-2,6-dienyl]ethane-1,2-diamine
- SQ 109; SQ-109; NSC 722041
- 1,2-Ethanediamine, N1-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-N2-tricyclo[3.3.1.13,7]dec-2-yl-
- SQ109 >=98% (HPLC)
- CAS:
- 502487-67-4
- MF:
- C22H38N2
- MW:
- 330.55
- Mol File:
- 502487-67-4.mol
SQ 109 Chemical Properties
- Boiling point:
- 450.0±33.0 °C(Predicted)
- Density
- 0.97±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
- form
- oil
- pka
- 9.80±0.20(Predicted)
- color
- colorless to yellow
SQ 109 Usage And Synthesis
Uses
SQ109 has been used:
- as an antitubercular?agent to study its interactions with mycobacterial membrane proteins large 3 (MmpL3) binding pocket
- as a positive control to determine the minimum inhibitory concentration (MIC) of ohmyungsamycins (OMS) A and B against Mycobacterium tuberculosis?(Mtb) using the resazurin microtiter assay (REMA) plate method
- as an inhibitor of MmpL3 to explore the utility of mycobacterial CRISPR interference for validating target gene essentiality and compound mode of action
General Description
SQ109 is a 1,2-ethylenediamine, which is related to ethambutol.
Biochem/physiol Actions
SQ109 exhibits activity against Helicobacter pylori and the fungi Candida albicans. It might also possess anti-bacterial activity.
in vivo
Oral administration of SQ109 (0.1-25 mg/kg per day) to the mice for 28 days results in dose-dependent reductions of mycobacterial load in both spleen and lung comparable to that of EMB administered at 100 mg/kg per day, but is less potent than isoniazid (INH) at 25 mg/kg per day. Pharmacokinetic profiles of SQ109 in mice following a single administration showed its Cmax as 1038 (intravenous (i.v.)) and 135 ng/mL (p.o.), with an oral Tmax of 0.31 h. The elimination t1/2 of SQ109 is 3.5 (i.v.) and 5.2 h (p.o.). The oral bioavailability is 4%[2]. The terminal half-life (t1/2) of SQ109 in dogs (12-29 h, mean 29.3 h) is longer than in rats (7-8 h, mean 7.4 h), as reflected by the significantly larger volume of distribution of SQ109 in dogs. The oral bioavailability of SQ109 in rats and dogs is determined to be 12% and 5%, respectively[3].
target
Mycobacterium
IC 50
Trypanosoma
SQ 109Supplier
- Tel
- 0510-83588313-811 18800520310
- sales@chemshuttle.com
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- 021-58950125
- info@chemexpress.com
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- 021-58955995
- sales@medchemexpress.cn
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
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- 025-58849295 18951903616;
- info@adooq.cn