1,11b-Dihydro-11b-hydroxyMedicarpin Chemical Properties

Boiling point:

490.0±45.0 °C(Predicted)

Density 

1.40±0.1 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

13.53±0.20(Predicted)

1,11b-Dihydro-11b-hydroxyMedicarpin Usage And Synthesis

Uses

1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].

References

[1] Alejandro F.Barrero, et al. Pterocarpans from Ononis viscosa subsp. breviflora. Phytochemistry. 1998 May, 48 (1): 187-190.
[2] Manisha Dixit, et al. Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways. PLoS One. 2015 Dec 11;10(12):e0144541. DOI:10.1371/journal.pone.0144541
[3] Mohd Nizam Mansoori, et al. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Int Immunopharmacol. 2020 Feb 22;82:106299. DOI:10.1016/j.intimp.2020.106299

1,11b-Dihydro-11b-hydroxyMedicarpin(210537-04-5)Related Product Information

• alpha-Cyperone
• Hydroxyecdysone
• beta-Sitosterol
• 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one
• hydroxygenkwanin
• Artemether
• alpha-Terpineol
• beta-Eudesmol
• (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one
• MOSLOFLAVONE