1-(4-thio-beta-D-ribofuranosyl)uracil Chemical Properties

Melting point:

195-196 °C(Solv: chloroform (67-66-3); ethanol (64-17-5))

Density 

1.687±0.06 g/cm3(Predicted)

pka

9.39±0.10(Predicted)

form 

Solid

color 

White to off-white

1-(4-thio-beta-D-ribofuranosyl)uracil Usage And Synthesis

Uses

4′-Thiouridine (1-(4-thio-beta-D-ribofuranosyl)uracil) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005