ETHYL 2-METHYL-5-NITRONICOTINATE Chemical Properties

Melting point:

64-65 °C

Boiling point:

309.6±37.0 °C(Predicted)

Density 

1.272±0.06 g/cm3(Predicted)

storage temp. 

Store at room temperature

pka

-0.02±0.20(Predicted)

Appearance

White to yellow Solid

ETHYL 2-METHYL-5-NITRONICOTINATE Usage And Synthesis

Synthesis

General procedure for the synthesis of ethyl 2-methyl-5-nitronicotinate from nitromalonaldehyde and ethyl 3-aminocrotonate: nitromalonaldehyde (416 g, 3.6 mol) and ethyl 3-aminocrotonate (339 g, 2.6 mol) were added to a solvent mixture consisting of ethanol (1.9 L), water (1.9 L) and glacial acetic acid (240 mL). The reaction mixture was stirred and reacted at 50 °C overnight. Upon completion of the reaction, the reaction solution was concentrated by distillation under reduced pressure. The concentrated residue was dissolved in dichloromethane (5.0 L) and filtered to remove insoluble matter. The filtrate was concentrated and purified by column chromatography (eluent ratio: ethyl acetate:petroleum ether = 1:10) to afford the target product ethyl 2-methyl-5-nitronicotinate (165 g, 30% yield) as a white solid. The product was characterized by 1H NMR (CDCl3, 300 MHz): δ= 1.23-1.26 (t, 3H), 2.25 (s, 3H), 4.14-4.21 (q, 2H), 8.91-8.92 (t, 1H), 9.37-9.38 (d, 1H).LC-MS analysis showed that the [M + 1]+ peak was located at 210.2.

References

[1] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 33-34

ETHYL 2-METHYL-5-NITRONICOTINATE(51984-71-5)Related Product Information

• ETHYL STEARATE
• 5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER
• 5-AMINO-2-METHYL-NICOTINIC ACID ETHYL ESTER
• 3-AMINO-5-HYDROXYMETHYLPYRIDINE
• 3-METHYL-5-NITROPYRIDINE
• Ethyl nicotinate
• 5-Aminonicotinic acid
• 2-Methyl-5-nitropyridine
• ETHYL 2-METHYL-5-NITRONICOTINATE
• 5-AMINO-NICOTINIC ACID METHYL ESTER
• 5-NITRONICOTINIC ACID
• 5-Amino-2-methylpyridine
• 5,6-DIMETHYL-PYRIDIN-3-YLAMINE
• 5-NITRONICOTINALDEHYDE
• 5-Amino-3-pyridinecarboxylic acid ethyl ester
• 2-METHYL-5-NITRONICOTINIC ACID
• ETHYL 5-NITRO-2-PROPYLNICOTINATE
• ETHYL 2-ETHYL-5-NITRONICOTINATE