5-Bromo-3-nitro-2-pyridinol Chemical Properties

Melting point:

246-250 °C

Boiling point:

296.7±40.0 °C(Predicted)

Density 

1.98±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO, Methanol

pka

6.31±0.10(Predicted)

form 

Solid

color 

Yellow

BRN 

383853

InChI

InChI=1S/C5H3BrN2O3/c6-3-1-4(8(10)11)5(9)7-2-3/h1-2H,(H,7,9)

InChIKey

WXRLCVUDLFFTFF-UHFFFAOYSA-N

SMILES

C1(=O)NC=C(Br)C=C1[N+]([O-])=O

CAS DataBase Reference

15862-34-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-37/38-41-36/37/38-20

Safety Statements 

26-36/37/39-36

RIDADR 

2811

WGK Germany 

3

Hazard Note 

Harmful

HazardClass 

IRRITANT

HS Code 

29337900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

5-Bromo-3-nitro-2-pyridinol Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

5-Bromo-3-nitropyridin-2(1H)-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

GENERAL METHOD: 2-amino-3-nitro-5-bromopyridine (0.015 mol) was dissolved in 70% sulfuric acid under cooling in an ice bath. A solution prepared from sodium nitrite (1.24 g) dissolved in water (8 mL) was slowly added dropwise in the range of 0-5°C, keeping the reaction temperature constant. After the dropwise addition, the reaction mixture was allowed to warm up gradually to room temperature and stirred continuously at that temperature for 3 hours. After completion of the reaction, the resulting precipitate was separated by filtration, washed well with deionized water and finally dried under vacuum at 60 °C overnight.

References

[1] Tetrahedron, 2014, vol. 70, # 5, p. 1077 - 1083
[2] Journal of the Chemical Society, 1952, p. 2042,2044
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 9, p. 1036 - 1040

5-Bromo-3-nitro-2-pyridinol(15862-34-7)Related Product Information

• 4-Ethyl-5-fluoro-6-hydroxypyrimidine
• 2,5-Dimethylpyridine
• CHLOROPHOSPHONAZO III
• 3-Nitro-2-pyridinol
• 2-Chloro-5-chloromethylpyridine
• 3-Nitropyridine
• 4-Hydroxy-3-nitropyridine
• Bromonitromethane
• 1-Hexadecylpyridinium bromide
• 5-Bromo-2-chloro-3-nitropyridine
• NITROGEN DIOXIDE
• 5-BROMO-2-METHOXY-3-NITRO-PYRIDINE
• 5-Bromo-2-methoxy-4-methyl-3-nitropyridine
• 3-BROMO-5-NITRO-2-PYRIDINOL
• 2-HYDROXY-3-NITROPYRIDINE
• 2-Hydroxy-5-bromopyridine
• 5-BROMO-2-HYDROXY-3-NITRO-4-PICOLINE
• Bromine