6-O-Benzylguanine Chemical Properties

Melting point:

193(dec.)

Boiling point:

459.3±55.0 °C(Predicted)

Density 

1.48±0.1 g/cm3(Predicted)

storage temp. 

room temp

solubility 

methanol: 20 mg/mL

form 

solid

pka

7.47±0.20(Predicted)

color 

Off-White to Light Yellow

CAS DataBase Reference

19916-73-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich

6-O-Benzylguanine Usage And Synthesis

Chemical Properties

Light Yellow Solid

Uses

An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.

Uses

O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Biochem/physiol Actions

O6-Benzylguanine (O6BG) inhibits methylguanine methyltransferase (MGMT) by blocking the active site through benzyl group transfer. The use of O6BG with bis-chloroethylnitrosourea (BCNU) or carmustine is effective in treating solid tumors including lymphomas, melanomas and sarcoma.

6-O-Benzylguanine(19916-73-5)Related Product Information

• EC 2.6.1.2
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• Benzyl chloride
• 3-Aminophenol
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• ALTRENOGEST
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• 4-Methoxybenzylchloride
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