Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Inhibitors >  Stem Cells & Wnt >  Wnt / beta-catenin inhibitors >  IWP L6

IWP L6

Basic information Safety Supplier Related

IWP L6 Basic information

Product Name:
IWP L6
Synonyms:
  • IWP L6
  • 2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyriMidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetaMide
  • N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
  • Porcn Inhibitor III
  • N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide IWP-L6
  • 2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide
  • CS-1445
  • IWP-L6, >=98%
CAS:
1427782-89-5
MF:
C25H20N4O2S2
MW:
472.58
Product Categories:
  • Inhibitors
Mol File:
1427782-89-5.mol
More
Less

IWP L6 Chemical Properties

storage temp. 
Store at -20° C
solubility 
≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
color 
White to off-white
More
Less

IWP L6 Usage And Synthesis

Uses

2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide is an inhibitor of Porcupine, a member of the membrane-bound O-acyltransferase family of proteins.

Biological Activity

iwp-l6 is an inhibitor of porcupine with ic50 value of 0.5nm [1].iwp-l6 is developed as a sub-nanomolar inhibitor.of porcupine. it targets the wnt signaling since porcupine is the enzyme to catalyze the palmitoylation of wnt proteins. in hek293 cells, iwp-l6 is found to inhibi the phosphorylation of dishevelled 2 (dvl2) significantly. iwp-l6 has good stability in human plasma but weaker stability in rat and mouse plasma. in vivo assay shows that iwp-l6 is quite active in zebrafish. it blocks the regeneration of the tailfin effectively. it also shows inhibition of posterior axis formation at low micromolar concentrations. additionally, in cultured mouse embryonic kidneys, 10nm iwp-l6 can significantly reduce branching morphogenesis while 50nm iwp-l6 completely blocks wnt signaling [1].

storage

+4°C

References

[1] wang x, moon j, dodge me, pan x, zhang l, hanson jm, tuladhar r, ma z, shi h, williams ns, amatruda jf, carroll tj, lum l, chen c. the development of highly potent inhibitors for porcupine. j med chem. 2013 mar 28;56(6):2700-4.

IWP L6Supplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
More
Less

IWP L6(1427782-89-5)Related Product Information