Basic information Safety Supplier Related

GS9620

Basic information Safety Supplier Related

GS9620 Basic information

Product Name:
GS9620
Synonyms:
  • CS-925
  • GS 9620; GS9620
  • Vesatolimod
  • GS9620, >=98%
  • 4-amino-2-butoxy-8-[[3-(pyrrolidin-1-ylmethyl)phenyl]methyl]-5,7-dihydropteridin-6-one
  • 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one
  • 4-Amino-2-butoxy-8-[3-(1-pyrrolidinylmethyl)benzyl]-7,8-dihydro-6(5H)-pteridinone
  • GS 9620
CAS:
1228585-88-3
MF:
C22H30N6O2
MW:
410.51
Product Categories:
  • API
Mol File:
1228585-88-3.mol
More
Less

GS9620 Chemical Properties

Density 
1.247±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (10 mg/ml)
form 
solid
pka
10.34±0.20(Predicted)
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
More
Less

GS9620 Usage And Synthesis

Description

GS-9620 is a potent and selective oral Toll-like receptor 7 (TLR7) agonist that directly activates plasmacytoid dendritic cells (pDCs). GS-9620 suppressed hepatitis B virus (HBV) in animal models of chronic infection and transiently activated HIV expressionex vivoin latently-infected peripheral blood mononuclear cells (PBMCs) from virally suppressed patients. Currently, GS-9620 is under clinical evaluation for treating chronic HBV infection and for reducing latent reservoirs in virally-suppressed HIV-infected patients.

target

TLR-7

References

Lopatin, U, et al. "Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist." Antiviral Therapy18.3(2013):409-18.
Gane, E. J., et al. "The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection." Journal of Hepatology63.2(2015):320.
Lanford, Robert E., et al. "GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees." Gastroenterology 144.7(2013):1508.

GS9620Supplier

Changzhou Chenhong Biotechnology Co., Ltd. Gold
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
Shanghai tingchong biology science and technology co., ltd Gold
Tel
18964309092 18964309092
Email
2769493375@qq.com
Chengdu Celes Technology Co., Ltd Gold
Tel
17323066073
Email
2538834896@qq.com
Deyang Sino Biotech. Co., LTD Gold
Tel
+86-19182167371 +86-19182167371
Email
service@synlord.com
Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com