Sitagliptin IMpurity Chemical Properties

Melting point:

113-115°C

Boiling point:

504.1±60.0 °C(Predicted)

Density 

1.52±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

-0.03±0.20(Predicted)

color 

White to Off-White

InChI

InChI=1S/C16H12F6N4O/c17-10-7-12(19)11(18)6-9(10)2-1-3-14(27)25-4-5-26-13(8-25)23-24-15(26)16(20,21)22/h1-2,6-7H,3-5,8H2

InChIKey

BLDAVCZELRQXFP-UHFFFAOYSA-N

SMILES

C(N1CCN2C(C(F)(F)F)=NN=C2C1)(=O)CC=CC1=CC(F)=C(F)C=C1F

Sitagliptin IMpurity Usage And Synthesis

Uses

1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-3-buten-1-one is a derivative of Sitagliptin(S491000) which is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.

Sitagliptin IMpurity(1675201-14-5)Related Product Information

• Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
• (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione
• Sitagliptin Impurity 31
• Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-
• (R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid
• Sitagliptin Impurity 26
• Sitagliptin Defuoro IMpurity 3
• Sitagliptin DeaMino IMpurity 1
• Sitagliptin
• Sitagliptin Impurity 1
• Sitagliptin EP Impurity B
• Sitagliptin Impurity 14
• Sitagliptin Defuoro IMpurity 5
• 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
• Sitagliptin Impurity 34
• Sitagliptin N-Phoshate IMpurity
• Sitagliptin phosphate
• Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate