Basic information Safety Supplier Related

NISOXETINE HYDROCHLORIDE

Basic information Safety Supplier Related

NISOXETINE HYDROCHLORIDE Basic information

Product Name:
NISOXETINE HYDROCHLORIDE
Synonyms:
  • LY-94,939
  • (+/-)-GAMMA-(2-METHOXYPHENOXY)-N-METHYL-BENZENEPROPANAMINE HYDROCHLORIDE
  • NISOXETINE HYDROCHLORIDE
  • NISOXETINE HYDROCHLORIDE (LY-94,939) NOR PINEPHRINE UPTAKE
  • (+/-)-g-(2-Methoxyphenoxy)-N-methylbenzenepropanaminehydrochloride
  • NisoxetineHCl
  • Nsc298819
  • (±)-γ-(2-methoxyphenoxy)-n-methyl-benzenepropanamine hydrochloride
CAS:
57754-86-6
MF:
C17H22ClNO2
MW:
307.82
Product Categories:
  • Adrenoceptor
Mol File:
57754-86-6.mol
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NISOXETINE HYDROCHLORIDE Chemical Properties

storage temp. 
Sealed in dry,Room Temperature
solubility 
H2O: 20 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble to 100 mM in water
InChI
InChI=1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H
InChIKey
LCEURBZEQJZUPV-UHFFFAOYSA-N
SMILES
C(CCNC)(OC1=CC=CC=C1OC)C1C=CC=CC=1.Cl
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Safety Information

Safety Statements 
22-26-36
WGK Germany 
3
RTECS 
NI2922170

MSDS

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NISOXETINE HYDROCHLORIDE Usage And Synthesis

Uses

Nisoxetine Hydrochloride is a selective and potent inhibitor of norepinephrine transporter.

Biological Activity

A potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.

Biochem/physiol Actions

Nisoxetine?is a selective and potent noradrenaline reuptake inhibitor. It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity.

in vivo

Nisoxetine (2.2 μM; a single intrathecal injection) hydrochloride shows 100, 100, and 100% of blockades in motor function, proprioception, and with duration of action of about 61, 96, and 236 min, respectively[3].
Nisoxetine (3,10, 30 mg/kg, i.p.) hydrochloride inhibits refeeding response (intake of standard chow) in rats[4].

Animal Model:Sprague-Dawley rats(290-340 g)[3]
Dosage:0.6, 1.2, 1.8, 2.2 μM
Administration:A single intrathecal injection
Result:Showed ED50s of 0.82, 0.75 and 0.70 μM in blocking motor function, proprioception, and nociception respectively.

storage

Store at RT

NISOXETINE HYDROCHLORIDESupplier

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd Gold
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024-024-024-88590548 18341751992
Email
757984502@qq.com
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
Email
3bsc@sina.com
Sigma-Aldrich
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021-61415566 800-8193336
Email
orderCN@merckgroup.com
BOC Sciences
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16314854226
Email
info@bocsci.com
Pharmacodia (Beijing) Co.,Ltd
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+86-400-851-9921
Email
sales@pharmacodia.com
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