ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > Nilotinib hydrochloride anhydrous
Nilotinib hydrochloride anhydrous
Nilotinib hydrochloride anhydrous Basic information
- Product Name:
- Nilotinib hydrochloride anhydrous
- Synonyms:
-
- Nilotinib hydrochloride anhydrous
- Nilotinib hydrochloride
- 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}benzamide hydrochloride (1:1)
- AMN-107 HCl
- Nilotinib hydrochloride anhydrou
- Nilotinib hydrochloride anhydrous USP/EP/BP
- Nilotinib HCI
- Nilotinib hydrochloride, 10 mM in DMSO
- CAS:
- 923288-95-3
- MF:
- C28H23ClF3N7O
- MW:
- 565.99
- Mol File:
- 923288-95-3.mol
More
Less
Nilotinib hydrochloride anhydrous Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mg/mL (176.68 mM);Ethanol: 2 mg/mL (3.53 mM)
- Water Solubility
- Water: Insoluble
- InChIKey
- VTGGYCCJUPYZSX-UHFFFAOYSA-N
- SMILES
- C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)(=O)C1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1.Cl
More
Less
Nilotinib hydrochloride anhydrous Usage And Synthesis
Uses
Nilotinib Hydrochloride might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.
in vivo
Nilotinib hydrochloride (oral gavage, 40 mg/kg, daily, 4 weeks) shows equivalent or higher antitumor effects in BALB/cSLc-nu/nu mice with GIST xenograft[2].
Nilotinib hydrochloride has a significant healing effect on the macroscopic and microscopic pathologic scores and ensures considerable mucosal healing in the indomethacin-induced enterocolitis rat model while decreases the PDGFR α and β levels and apoptotic scores in the colon[3].
| Animal Model: | BALB/cSLc-nu/nu mice with GIST xenograft (GK1X, GK2X and GK3X)[2] |
| Dosage: | 40 mg/kg |
| Administration: | Oral gavage; daily; 4 weeks |
| Result: | Inhibited tumor growth by 69.6% in GK1X, 85.3% in GK2X and 47.5% in GK3X xenograft line. |
Nilotinib hydrochloride anhydrousSupplier
Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
Taizhou Tongxin Bio-Tech Co., Ltd
- Tel
- 0523-86818997 18652728585
- sales@allyrise.com
Porse Fine Chemical Co.,LTD
- Tel
- 20-66003216 18666003216
- info@porsefinechemical.com
Nanjing First Pharmaceutical Co., Ltd.
- Tel
- 025-83172655 13585105703
- sales@njfirstpharm.com
Yangzhou QinYuan Pharmaceutical Co., Ltd.
- Tel
- 0514-80939770 13773367191
- yzqyyykj@163.com