EthanediaMide iMpurity F Chemical Properties

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

form 

Solid

pka

9.46±0.70(Predicted)

Appearance

White to off-white Solid

EthanediaMide iMpurity F Usage And Synthesis

Uses

Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention[1][2].

References

[1] Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6(9):1542-9. DOI:10.1111/j.1538-7836.2008.03064.x
[2] Mendell J, Lee F, Chen S, The Effects of the Antiplatelet Agents, Aspirin and Naproxen, on Pharmacokinetics and Pharmacodynamics of the Anticoagulant Edoxaban, a Direct Factor Xa Inhibitor. J Cardiovasc Pharmacol. 2013 Apr 23. DOI:10.1097/FJC.0b013e3182970991

EthanediaMide iMpurity F(480452-37-7)Related Product Information

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• tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate oxalate
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• (1R,3R,4R)-3-AMino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
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• 2-Amino-3-chloropyridine