Fluxapyroxad
Fluxapyroxad Basic information
- Product Name:
- Fluxapyroxad
- Synonyms:
-
- Fluxapyroxad
- 3-(Difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide
- Xemium
- 1H-Pyrazole-4-carboxaMide, 3-(difluoroMethyl)-1-Methyl-N-(3',4',5'-trifluoro[1,1'-biphenyl]-2-yl)-
- 3-(Difluoromethyl)-1-methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide
- 3-(DIFLUOROMETHYL)-1-METHYL-N-(3,4,5-TRIFLUORO-[1,1-BIPHENYL]-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE
- Fluxapyroxad@1000 μg/mL in Acetonitrile
- Fluxapyroxad@100 μg/mL in Acetonitrile
- CAS:
- 907204-31-3
- MF:
- C18H12F5N3O
- MW:
- 381.3
- Product Categories:
-
- 907204-31-3
- Mol File:
- 907204-31-3.mol
Fluxapyroxad Chemical Properties
- Boiling point:
- 428.4±45.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 100 mg/mL (262.26 mM)
- pka
- 11.73±0.70(Predicted)
- form
- Solid
- color
- White to off-white
- BRN
- 15702063
- InChI
- InChI=1S/C18H12F5N3O/c1-26-8-11(16(25-26)17(22)23)18(27)24-14-5-3-2-4-10(14)9-6-12(19)15(21)13(20)7-9/h2-8,17H,1H3,(H,24,27)
- InChIKey
- SXSGXWCSHSVPGB-UHFFFAOYSA-N
- SMILES
- N1(C)C=C(C(NC2=CC=CC=C2C2=CC(F)=C(F)C(F)=C2)=O)C(C(F)F)=N1
- EPA Substance Registry System
- 1H-Pyrazole-4-carboxamide, 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluoro[1,1'-biphenyl]-2-yl)- (907204-31-3)
Safety Information
- Hazard Codes
- Xn,N
- Risk Statements
- 40-50/53
- Safety Statements
- 36/37-60-61
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
Fluxapyroxad Usage And Synthesis
Chemical Properties
Flumioxazin is white crystal, melting point 156.8℃, relative density 1.42 (room temperature), vapor pressure (25℃) >8.1×10-9 Pa. Its solubility at room temperature (g/L, 20℃): acetone >250, acetonitrile 167.6±0.2, methylene chloride 146.1±0.3, ethyl acetate 123.3±0.2, methanol 53.4, toluene 20.0, n-octanol 4.69, n-heptane 0.106. Kow logP is 3.08 (deionized water, 3.09 (pH 4), n-heptanol 0.106. 20.0, n-octanol 4.69, n-heptane 0.106. octanol/water partition coefficients (20°C) Kow logP were 3.08 (deionized water), 3.09 (pH 4), 3.13 (pH 7), 3.09 (pH 9).
Uses
Fluxapyroxad is a new generation carboxamide funugicide and its residues are found in food. Pesticide component.
Definition
ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 3-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid with the amino group of 3',4',5'-trifluorobiphenyl-2-amine. Used to control a number of cereal fungal pathogens including those elonging to the Ascomycetes, Basidiomycetes and Zygomycetes families.
in vivo
Fluxapyroxad (10 mg/kg/day, po via diet for 13 weeks) induces the body weight gain reduction, colon length reduction, intestinal barrier integrity impairment and proinflammatory cytokines secretion, inducing chronic colonic inflammation in C57BL/6 J mice[2].
| Animal Model: | C57BL/6 J mouse model[2]. |
| Dosage: | 10 mg/kg/day |
| Administration: | po via diet for 13 weeks |
| Result: | Decreased body weight gain, shortened the colon length, damaged the colonic crypts, increased the levels of proinflammatory cytokines IL-6, IL-1β, and TNF-α, decreased the level of IL-22, impaired the intestinal barrier integrity. |
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