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UNC 669

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UNC 669 Basic information

Product Name:
UNC 669
Synonyms:
  • CS-1146
  • UNC 669; UNC-669
  • UNC 669
  • (5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone
  • UNC699
  • (5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone UNC669
  • UNC669, >=98%
  • (5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
CAS:
1314241-44-5
MF:
C15H20BrN3O
MW:
338.24
Product Categories:
  • API
  • Inhibitors
Mol File:
1314241-44-5.mol
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UNC 669 Chemical Properties

Boiling point:
458.0±45.0 °C(Predicted)
Density 
1.424±0.06 g/cm3(Predicted)
storage temp. 
Store at -20° C
solubility 
insoluble in H2O; ≥52.4 mg/mL in EtOH with ultrasonic; ≥9.35 mg/mL in DMSO
form 
solid
pka
9.78±0.20(Predicted)
color 
White to off-white
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UNC 669 Usage And Synthesis

Uses

(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT).

Definition

ChEBI: (5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is an aromatic carboxylic acid and a pyridinemonocarboxylic acid.

Biological Activity

unc 669 is a potent antagonist of l3mbtl1 (ic50=4.2 μm) and l3mbtl3 (ic50=3.1 μm).there is less bio-data supported for unc669. unc1679 is an analog of unc669. unc1215 is the first potent and selective antagonism of a methyl-lysine reader protein, l3mbtl3, which antagonizes the mono- and dimethyl-lysine reading function of l3mbtl3. [1]lysine methylation is a key epigenetic landmark, the dysregulation of which is related to many diseases. unc1679 maintains in vitro and cellular potency with improved selectivity against other mbt-containing proteins. the antagonists described were also found to effectively interact with unlabeled endogenous l3mbtl3 in cells. [1]

target

L3MBTL1

References

1. james li, korboukh vk, krichevsky l et al. small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for l3mbtl3. j med chem. 2013 sep 26;56(18):7358-71. doi: 10.1021/jm400919p. epub 2013 sep 16.

UNC 669Supplier

Shanghai Boyle Chemical Co., Ltd.
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