UNC 669
UNC 669 Basic information
- Product Name:
- UNC 669
- Synonyms:
-
- CS-1146
- UNC 669; UNC-669
- UNC 669
- (5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone
- UNC699
- (5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone UNC669
- UNC669, >=98%
- (5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
- CAS:
- 1314241-44-5
- MF:
- C15H20BrN3O
- MW:
- 338.24
- Product Categories:
-
- API
- Inhibitors
- Mol File:
- 1314241-44-5.mol
UNC 669 Chemical Properties
- Boiling point:
- 458.0±45.0 °C(Predicted)
- Density
- 1.424±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20° C
- solubility
- insoluble in H2O; ≥52.4 mg/mL in EtOH with ultrasonic; ≥9.35 mg/mL in DMSO
- form
- solid
- pka
- 9.78±0.20(Predicted)
- color
- White to off-white
UNC 669 Usage And Synthesis
Uses
(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT).
Definition
ChEBI: (5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is an aromatic carboxylic acid and a pyridinemonocarboxylic acid.
Biological Activity
unc 669 is a potent antagonist of l3mbtl1 (ic50=4.2 μm) and l3mbtl3 (ic50=3.1 μm).there is less bio-data supported for unc669. unc1679 is an analog of unc669. unc1215 is the first potent and selective antagonism of a methyl-lysine reader protein, l3mbtl3, which antagonizes the mono- and dimethyl-lysine reading function of l3mbtl3. [1]lysine methylation is a key epigenetic landmark, the dysregulation of which is related to many diseases. unc1679 maintains in vitro and cellular potency with improved selectivity against other mbt-containing proteins. the antagonists described were also found to effectively interact with unlabeled endogenous l3mbtl3 in cells. [1]
target
L3MBTL1
References
1. james li, korboukh vk, krichevsky l et al. small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for l3mbtl3. j med chem. 2013 sep 26;56(18):7358-71. doi: 10.1021/jm400919p. epub 2013 sep 16.
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