Etilefrine hydrochloride
Etilefrine hydrochloride Basic information
- Product Name:
- Etilefrine hydrochloride
- Synonyms:
-
- alpha-((ethylamino)methyl)-m-hydroxybenzylalcoholhydrochloride
- 3-[2-(ETHYLAMINO)-1-HYDROXYETHYL]PHENOL HYDROCHLORIDE
- 2-ETHYLAMINO-1-(3-HYDROXYPHENYL)ETHANOL HYDROCHLORIDE
- LABOTEST-BB LT00244796
- Etilefrina
- ETILEFRIN HYDROCHLORIDE 98+%
- (+-)-Ethylphenylephrine hydrochloride
- dl-n-ethylnorphenylephrine hydrochloride
- CAS:
- 943-17-9
- MF:
- C10H16ClNO2
- MW:
- 217.69
- EINECS:
- 213-398-8
- Mol File:
- 943-17-9.mol
Etilefrine hydrochloride Chemical Properties
- Melting point:
- 122 °C
- storage temp.
- -20°C
- solubility
- Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride
Etilefrine hydrochloride Usage And Synthesis
Chemical Properties
White or almost white, crystalline powder or colourless crystals.
Originator
Circupon,Troponwerke,W. Germany
Uses
Adrenoceptor agonist.
Definition
ChEBI: Etilefrine hydrochloride (TN) is a member of phenols.
Manufacturing Process
30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are
mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and
dissolved while warming. After heating for 1 hour under reflux, the acylation
is complete. After concentrating the reaction solution, the product is
precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2-
(N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water,
thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan-
1-one, dissolved in a 10-fold amount of water, are added dropwise at room
temperature and hydrogenation is carried out until 1 mol of hydrogen has
been taken up. After filtering off the catalyst, a further 3 parts of
palladium/charcoal are added and hydrogenation is carried out until a further
mol of hydrogen has been taken up. The catalyst is separated off and after
removal of the solvent the hydrogenation product is reprecipitated from
acetone/petroleum ether and from methanol/ether until it is pure according to
thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2-
ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.
Therapeutic Function
Tranquilizer
Etilefrine hydrochloride Supplier
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