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Etilefrine hydrochloride

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Etilefrine hydrochloride Basic information

Product Name:
Etilefrine hydrochloride
Synonyms:
  • alpha-((ethylamino)methyl)-m-hydroxybenzylalcoholhydrochloride
  • 3-[2-(ETHYLAMINO)-1-HYDROXYETHYL]PHENOL HYDROCHLORIDE
  • 2-ETHYLAMINO-1-(3-HYDROXYPHENYL)ETHANOL HYDROCHLORIDE
  • LABOTEST-BB LT00244796
  • Etilefrina
  • ETILEFRIN HYDROCHLORIDE 98+%
  • (+-)-Ethylphenylephrine hydrochloride
  • dl-n-ethylnorphenylephrine hydrochloride
CAS:
943-17-9
MF:
C10H16ClNO2
MW:
217.69
EINECS:
213-398-8
Mol File:
943-17-9.mol
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Etilefrine hydrochloride Chemical Properties

Melting point:
122 °C
storage temp. 
-20°C
solubility 
Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride
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Safety Information

RIDADR 
UN 2811 6.1 / PGIII
RTECS 
DO5618000
HS Code 
2922290090
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Etilefrine hydrochloride Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder or colourless crystals.

Originator

Circupon,Troponwerke,W. Germany

Uses

Adrenoceptor agonist.

Definition

ChEBI: Etilefrine hydrochloride (TN) is a member of phenols.

Manufacturing Process

30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and dissolved while warming. After heating for 1 hour under reflux, the acylation is complete. After concentrating the reaction solution, the product is precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2- (N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water, thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan- 1-one, dissolved in a 10-fold amount of water, are added dropwise at room temperature and hydrogenation is carried out until 1 mol of hydrogen has been taken up. After filtering off the catalyst, a further 3 parts of palladium/charcoal are added and hydrogenation is carried out until a further mol of hydrogen has been taken up. The catalyst is separated off and after removal of the solvent the hydrogenation product is reprecipitated from acetone/petroleum ether and from methanol/ether until it is pure according to thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2- ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.

Therapeutic Function

Tranquilizer

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