Val-cit-PAB-OH Chemical Properties

Melting point:

168 °C(dec.)

Boiling point:

715.0±60.0 °C(Predicted)

Density 

1.243±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

solubility 

DMF: 10 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml

form 

powder to crystal

pka

13.75±0.46(Predicted)

color 

White to Almost white

Safety Information

HS Code 

2924.29.7790

Val-cit-PAB-OH Usage And Synthesis

Description

Val-Cit-PAB-OH is a peptide cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B.

Uses

Val-cit-PAB-OH acts as a reagent in the preparation of cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy, preparation of monomethylvaline derivative conjugates with ligands and antibodies for cancer treatment.

Val-cit-PAB-OH(159857-79-1)Related Product Information

• Peptide synthesis
• ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE
• Peptide impurity
• peptide CRO
• OGP (Ostegenic Growth Peptide)
• Peptide phosphorylation marker
• Peptide fluorescent modification
• GMP peptide CMO
• L-Threonine, L-asparaginyl-L-alanyl-L-valyl-L-prolyl-L-asparaginyl-L-leucyl-L-arginylglycyl-L-α-aspartyl-L-leucyl-L-glutaminyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysyl-L-valyl-L-alanyl-L-arginyl-
• FMoc-Val-Cit-PAB-PNP
• pyrene-2,7-diyldiboronic acid
• Fmoc-Val-Cit-OH
• FMoc-Val-Cit-PAB
• MC-Val-Cit-PAB