ML365 Chemical Properties

Boiling point:

429.9±40.0 °C(Predicted)

Density 

1.253±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO:72.0(Max Conc. mg/mL);199.77(Max Conc. mM)
Ethanol:18.0(Max Conc. mg/mL);49.94(Max Conc. mM)

form 

Powder

pka

13.21±0.70(Predicted)

color 

White to off-white

InChI

1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)

InChIKey

UTAJHKSGYJSZBR-UHFFFAOYSA-N

SMILES

N(c2cc(ccc2)NC(=O)c3cc(ccc3)C)C(=O)c1c(cccc1)OC

Safety Information

WGK Germany 

WGK 3

Storage Class

13 - Non Combustible Solids

ML365 Usage And Synthesis

Uses

ML 365 acts as a potent and selective ASK-1 potassium channel blocker used in the regulation of cell membrane potential. This activity further modulates cell immune response, hormone changes, and neuronal function leading to various applications.

Biological Activity

Orignially characterized as an mGluR5 negative allosteric modulator (IC50 = 1.35 μM, Emax = 3.82% of Glu Emax; r at mGluR5 HEK293A cells), ML365 is now better known as selective two-pore potassium (K2P) channel TASK1 (K2P3.1; KCNK3) inhibitor with 100- and 62-fold selectivity over TASK3 (K2p9.1; KCNK9), respectively, by thellium flux (r at TASK1/TASK3 CHO cell IC50 = 4/390 nM) and QPatch assay (r at TASK1/TASK3 CHO cell IC50 = 16/990 nM). ML365 is employed in the range from 40 nM to 20 μM. Selective TASK1 blockage is achieved at the lower end of the concentration range, while TASK3 activity can also be inhibited at the high end of the range.

storage

Store at +4°C

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