((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate
((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate Basic information
- Product Name:
- ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate
- Synonyms:
-
- Dapagliflozin Impurity L
- Empagliflozin-4
- Dapagliflozin impurity 12/ O-Desethyl Dapagliflozin/(3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
- Daglitele Impurity 6
- (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
- Empagliflozin impurity H
- D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-hydroxyphenyl)methyl]phenyl]-, (1S)-
- Jardiance Impurity H
- CAS:
- 864070-37-1
- MF:
- C19H21ClO6
- MW:
- 380.82
- Mol File:
- 864070-37-1.mol
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((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate Chemical Properties
- Boiling point:
- 628.3±55.0 °C(Predicted)
- Density
- 1.459±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
- form
- A crystalline solid
- pka
- 10.17±0.15(Predicted)
- color
- White to off-white
- Stability:
- Hygroscopic
- InChI
- InChI=1/C19H21ClO6/c20-14-6-3-11(8-12(14)7-10-1-4-13(22)5-2-10)19-18(25)17(24)16(23)15(9-21)26-19/h1-6,8,15-19,21-25H,7,9H2/t15-,16-,17+,18-,19+/s3
- InChIKey
- ODQAIMBPQWETBE-YBDYQYBPNA-N
- SMILES
- O[C@@H]1[C@H]([C@H](O)[C@@H](CO)O[C@H]1C1C=CC(Cl)=C(CC2C=CC(O)=CC=2)C=1)O |&1:1,2,3,5,9,r|
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((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate Usage And Synthesis
Uses
O-Desethyl Dapagliflozin is derivative of antidiabetic drug Dapagliflozin (D185370), which is sodium-glucose transporter 2 inhibitor.
IC 50
SGLT2: 33 nM (IC50)
((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetateSupplier
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((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate(864070-37-1)Related Product Information
- (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol
- Empagliflozin Impurity 35
- Empagliflozin
- 2-Chloro-4'-fluorobenzophenone
- (R)-4-CHLORO-1,3-BUTANEDIOL
- (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
- Empagliflozin Impurity 23
- N/A
- Dapagliflozin Impurity 20
- EMpagliflozin iMpurity 14
- Butanoic acid, 4-chloro-3-hydroxy-, (3S)-
- (3R,4S,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)-2-methoxyoxane-3,4,5-triol
- Empagliflozin (R)-Isomer
- Dapagliflozin Impurity 19
- D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1R)-
- Acetoxy Empagliflozin
- (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxyMethyl)-2-Methoxytetrahydro-2H-pyran-3,4,5-triol
- GLP-1