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(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate

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(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate Basic information

Product Name:
(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate
Synonyms:
  • (1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate
  • tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)-benzoyl)piperazin-1-carboxylate
  • Bortezomib Impurity 53
  • Carbamic acid, N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester
CAS:
1187479-72-6
MF:
C29H45BN2O5
MW:
512.49
Mol File:
1187479-72-6.mol
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(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate Chemical Properties

Boiling point:
635.7±55.0 °C(Predicted)
Density 
1.10±0.1 g/cm3(Predicted)
pka
11.39±0.46(Predicted)
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(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate Usage And Synthesis

Uses

N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-Carbamic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of bortezomib (B675700).Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer.

(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronateSupplier

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