1-tert-Butyl 3-Methyl 4-aMino-1H-pyrazole-1,3-dicarboxylate Chemical Properties

Boiling point:

362.1±45.0 °C(Predicted)

Density 

1.29±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

0.05±0.10(Predicted)

1-tert-Butyl 3-Methyl 4-aMino-1H-pyrazole-1,3-dicarboxylate Usage And Synthesis

Synthesis

Synthesis of compound 26: To a solution of methanol (200 mL) containing compound 25 (14.7 g, 54.2 mmol) was added 10% wt Pd/C (2.88 g, 2.7 mmol). The reaction mixture was stirred for 4 hours at 1 atmosphere of hydrogen pressure. After completion of the reaction, the mixture was filtered through a diatomaceous earth plug and the filtrate was concentrated to give compound 26 (11.1 g, 85% yield). Electrospray mass spectrometry (ES(+)MS) showed m/e = 242 ([M + H]+).

References

[1] Patent: US2007/27166, 2007, A1. Location in patent: Page/Page column 84-85

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