GSK-LSD1 Chemical Properties

Boiling point:

347.4±42.0 °C(Predicted)

Density 

1.07±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

H2O: soluble20mg/mL, clear

form 

powder

pka

10.14±0.10(Predicted)

color 

white to beige

Safety Information

WGK Germany 

3

GSK-LSD1 Usage And Synthesis

Uses

GSK LSD1 Dihydrochloride is an irreversible mechanism-based inhibitor of LSD1. Lysine-specific demthylase 1 (LSD1) belonges to the flavin adenine dinucleotide (FAD) family-dependant amine oxidases that include MAOs and PAOs. Inhibits cell proliferation in cancer cell lines.

Uses

GSK-LSD1 has been used as a lysine specific demethylase 1 (LSD1) inhibitor in mice to study sepsis-induced mortality. It has also been used as an inhibitor to study if the effect of phenelzine activation of human immunodeficiency virus (HIV) latency is caused due to LSD1.

Biochem/physiol Actions

GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. For full characterization details, please visit the GSK-LSD1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

References

[1]. structural genomics consortium.http://www. thesgc.org/chemical-probes/lsd1.

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