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S-23

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S-23 Basic information

Product Name:
S-23
Synonyms:
  • Sarms powder
  • S-23 Sarms
  • S-23/S23 ,CAS NO 1010396-29-8 New Sarms Powder muslce building
  • S23 S 23 S-23
  • (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide
  • S-23
  • (S)-3-(4-Chloro-3-fluorophenoxy)-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide
  • (2S)-3-(4-Chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
CAS:
1010396-29-8
MF:
C18H13ClF4N2O3
MW:
416.75
EINECS:
1532714-185-1
Product Categories:
  • 1010396-29-8
  • SARMS
Mol File:
1010396-29-8.mol
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S-23 Chemical Properties

Melting point:
119-121 °C
Boiling point:
577.1±50.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
12.04±0.29(Predicted)
form 
Solid
color 
White to Off-White
optical activity
[α]/D 20±3°, c = 0.1 in chloroform
BRN 
19161994
InChI
InChI=1S/C18H13ClF4N2O3/c1-17(27,9-28-12-4-5-14(19)15(20)7-12)16(26)25-11-3-2-10(8-24)13(6-11)18(21,22)23/h2-7,27H,9H2,1H3,(H,25,26)/t17-/m0/s1
InChIKey
SSFVOEAXHZGTRJ-KRWDZBQOSA-N
SMILES
C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)(=O)[C@](O)(C)COC1=CC=C(Cl)C(F)=C1
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-53
WGK Germany 
3
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S-23 Usage And Synthesis

Description

S-23, the orally bioavailable nonsteroidal SARM, is appreciated by jocks over the world for its one of a kind capacity to improve fit bulk and bone tissue. A more secure option in contrast to anabolic steroid, this particular androgen receptor modulator is incredibly powerful to lose obstinate fat. Considered by numerous individuals as an amazing form of S-4 (Andarine), S-23 is a standout amongst other execution upgrading medications to solidify muscle and increase a grainier stylish look.

Uses

S 23 is a selective androgen receptor modulator.

benefits

Increments both skeletal and bulk
Advances durable bulk and perseverance gains
Perfect for muscle solidifying
Totally sets off catabolism in a calorie shortage
Builds bone quality and decreases fat mass
Improves drive in people
Encourages clients to hold increases long after a cycle
No swelling or liquid maintenance
Step by step instructions to Use S-23

Biological Activity

S-23 is a selective androgen receptor modulator (SARM). It binds to the AR (Ki = 1.7 nM) and induces AR-mediated transcriptional activation in CV-1 cells expressing the human receptor when used at a concentration of 10 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats. It decreases testicular sperm concentration without reducing mounting behavior or the number of intromissions in intact rats when administered in combination with estradiol benzoate (Item No. 10006487). S-23 (3 mg/kg) also increases preference for sexually active intact males when administered to ovariectomized female rats.

Clinical Use

S-23 is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolic to androgenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment.

References

[1] JONES A, CHEN J, HWANG D J, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception.[J]. Endocrinology, 2009, 150 1: 385-395. DOI:10.1210/en.2008-0674.
[2] JONES A, HWANG D J, DUKE C B, et al. Nonsteroidal Selective Androgen Receptor Modulators Enhance Female Sexual Motivation[J]. Journal of Pharmacology and Experimental Therapeutics, 2010, 334: 439-448. DOI:10.1124/jpet.110.168880.

S-23Supplier

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