Acetylene-PEG5-acid Chemical Properties

Boiling point:

426.3±45.0 °C(Predicted)

Density 

1.127±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

4.28±0.10(Predicted)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

WGK Germany 

3

Acetylene-PEG5-acid Usage And Synthesis

Description

Propargyl-PEG5-acid has a propargyl group at one end and an acid group at the other end. The acid can react with primary amines to form a stable amide bond, activation will be needed. The PEG units enhances solubility of the molecule in aqueous environment. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.

Uses

Propargyl-peg5 Acid is used as a reactant in the preparation of site-specific antibody-pyrrolobenzodiazepine conjugates.

Uses

Alkyne-PEG5-acid may be used in the synthesis of peptide nucleic acid (PNA) oligomers that can conjugate with vitamin B₁₂ via Cu-catalyzed 1,3-dipolar cycloaddition in order to study if vitamin B₁₂ to transport PNA oligonucleotides into bacterial cells.

Acetylene-PEG5-acid(1245823-51-1)Related Product Information

• Propargyl-PEG5-alcohol
• Propargyl-PEG8-acid
• Aminooxy-PEG4-Propargyl
• Propargyl-PEG3-Bromide
• Aminoxy-PEG3-Propargyl
• Propargyl-PEG7-acid
• Aminooxy-PEG1-propargyl
• Propargyl-PEG4-bromide
• Propargyl-PEG6-acid
• Propargyl-PEG4-methylamine
• Propargyl-PEG4-thiol
• Propargyl-PEG10-acid
• Propargyl-PEG2-methylamine
• Propargyl-PEG4-acid
• Propargyl-PEG5-t-butyl ester
• Propargyl-PEG3-t-butyl ester
• Propargyl-PEG5-Mes
• Propargyl-PEG5-CH2CO2tBu